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Titolo:
Evidence against a role of physiological concentrations of estrogen in post-myocardial infarction remodeling
Autore:
Hugel, S; Reincke, M; Stromer, H; Winning, J; Horn, M; Dienesch, C; Mora, P; Schmidt, HHHW; Allolio, B; Neubauer, S;
Indirizzi:
Univ Wurzburg, Med Klin, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 d Klin, D-97080 Wurzburg, Germany Univ Wurzburg, Inst Pharmakol & Toxikol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 oxikol, D-97080 Wurzburg, Germany
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 5, volume: 34, anno: 1999,
pagine: 1427 - 1434
SICI:
0735-1097(19991101)34:5<1427:EAAROP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR MASS; CORONARY HEART-DISEASE; SEX-DIFFERENCES; CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN; ENERGY-METABOLISM; BLOOD-PRESSURE; NITRIC-OXIDE; RAT-HEART; FOLLOW-UP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Hugel, S Univ Wurzburg, Med Klin, Josef Schneider Str 2, D-97080 Wurzburg,Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080 any
Citazione:
S. Hugel et al., "Evidence against a role of physiological concentrations of estrogen in post-myocardial infarction remodeling", J AM COL C, 34(5), 1999, pp. 1427-1434

Abstract

OBJECTIVES: The purpose of this study was to examine whether endogenous estrogen deficiency induced by ovariectomy affects chronic left ventricular dysfunction post-myocardial infarction (MI). BACKGROUND: Epidemiologic findings suggest that mortality of postmenopausal women is increased after MI, but the underlying mechanisms are unknown. Rats were either not ovariectomized (non-OVX), ovariectomized (OVX) or ovariectomized and treated with subcutaneous 17-beta-estradiol (E-2) pellets (OVX + E-2). Two weeks later, animals were sham-operated (Sham) or left coronary artery ligated (MI). Eight weeks later, in vivo echocardiographic and hemodynamic measurements were performed. Thereafter, hearts were isolated andperfused isovolumically. RESULTS: Mean infarct size was similar among the three MI groups. Ovariectomy decreased serum E-2 levels (11 +/- 4 vs. 49 +/- 11 pg/ml in non-OVX, p < 0.01) and increased body weight. These changes were reversed by E-2 replacement. The degree of cardiac hypertrophy was similar for all groups post-MI. Left Ventricular diameters were increased post-MI (8.9 +/- 0.4 in non-OVX + MI vs. 6.7 +/- 0.2 mm in non-OVX + Sham hearts, p < 0.0001), but OVX orOVX + E-2 replacement did not alter left ventricular diameters in post-MI and Sham hearts. Left Ventricular fractional shortening was severely impaired post-MI (19 +/- 2% vs. 50 +/- 3 in non-OVX + Sham hearts, p < 0.0001) with no influence of hormonal status. Left ventricular end-diastolic pressure, measured in vivo, was increased in all MI groups without significant differences between groups. Pressure-volume curves, obtained in perfused hearts, demonstrated a right and downward shift with reduced maximum left ventricular developed pressure post-MI (75 +/- 6 vs. 108 +/- 3 mm Hg in non-OVX + Sham hearts, p < 0.001) and were also unaffected by either OVX or E-2 replacement. CONCLUSIONS: Chronic endogenous estrogen deficiency does not have major effects on the development of cardiac hypertrophy, dysfunction and dilation post-MI. (C) 1999 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:03:37