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Titolo:
Toxoplasma gondii: Difference of invasion into tissue of digestive organs between susceptible and resistant strain and influence of IFN-gamma in miceinoculated with the cysts perorally
Autore:
Kobayashi, M; Aosai, F; Hata, H; Mun, HS; Tagawa, Y; Iwakura, Y; Yano, A;
Indirizzi:
Chiba Univ, Sch Med, Dept Parasitol, Chiba 280, Japan Chiba Univ Chiba Japan 280 iv, Sch Med, Dept Parasitol, Chiba 280, Japan Univ Tokyo, Inst Med Sci, Lab Anim Ctr, Tokyo, Japan Univ Tokyo Tokyo Japan Tokyo, Inst Med Sci, Lab Anim Ctr, Tokyo, Japan
Titolo Testata:
JOURNAL OF PARASITOLOGY
fascicolo: 5, volume: 85, anno: 1999,
pagine: 973 - 975
SICI:
0022-3395(199910)85:5<973:TGDOII>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOTOXIC T-LYMPHOCYTES; MURINE SUSCEPTIBILITY; ANTIGEN PRESENTATION; INTERFERON-GAMMA; MELANOMA-CELLS; CONGENIC MICE; INFECTION; KINETICS; NUMBER; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Kobayashi, M Chiba Univ, Sch Med, Dept Parasitol, 1-8-1 Inohana, Chiba 280, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 280 a, Chiba 280, Japan
Citazione:
M. Kobayashi et al., "Toxoplasma gondii: Difference of invasion into tissue of digestive organs between susceptible and resistant strain and influence of IFN-gamma in miceinoculated with the cysts perorally", J PARASITOL, 85(5), 1999, pp. 973-975

Abstract

Because it is widely accepted that there is a significant difference in susceptibility to chronic infection by Toxoplasma gondii among inbred mouse strains with different genetic backgrounds, we compared the distribution of the protozoa in digestive organs at early stages of infection between resistant (BALB/c) and susceptible (C57BL/6) mice after peroral infection with Fukaya strain cysts. Furthermore, to determine the influence of interferon gamma (IFN-gamma) on the infectivity of the cysts to the digestive tract, homozygous IFN-gamma knockout mice were utilized. Quantitative competitive polymerase chain reaction (QC-PCR) was employed to assess the distribution ofT. gondii in different organs at Various times after ingestion of cysts. SAG1, a T. gondii-specific gene, was detected in the small intestine and thecaecum in wild-type C57BL/6 mice and in the whole digestive tract in IFN-gamma knockout C57BL/6 at 24 kr after infection. No detectable reaction in QC-PCR was observed in BALB/c mice at 24 hr after ingestion of the cysts. Destruction of the IFN-gamma gene showed less effect on the resistance to infection in BALB/c mice, but remarkable augmentation of infectivity of T. gondii to the rectum and peripheral blood was observed in C57BL/6 mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:50:49