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Titolo:
Human herpesviruses 6 and 7 as potential pathogens after liver transplant:Prospective comparison with the effect of cytomegalovirus
Autore:
Griffiths, PD; Ait-Khaled, M; Bearcroft, CP; Clark, DA; Quaglia, A; Davies, SE; Burroughs, AK; Rolles, K; Kidd, IM; Knight, SN; Noibi, SM; Cope, AV; Phillips, AN; Emery, VC;
Indirizzi:
Royal Free & Univ Coll, Sch Med, Dept Virol, London, England Royal Free & Univ Coll London England Med, Dept Virol, London, England Royal Free & Univ Coll, Sch Med, Dept Med, London, England Royal Free & Univ Coll London England ch Med, Dept Med, London, England Royal Free & Univ Coll, Sch Med, Dept Histopathol, London, England Royal Free & Univ Coll London England Dept Histopathol, London, England Royal Free & Univ Coll, Sch Med, Acad Dept Surg, London, England Royal Free & Univ Coll London England , Acad Dept Surg, London, England Royal Free Hosp, Dept Primary Care & Populat Sci, London NW3 2QG, England Royal Free Hosp London England NW3 2QG ulat Sci, London NW3 2QG, England
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 4, volume: 59, anno: 1999,
pagine: 496 - 501
SICI:
0146-6615(199912)59:4<496:HH6A7A>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; BONE-MARROW TRANSPLANTATION; ANTIVIRALS INVITRO; PERIPHERAL-BLOOD; RISK-FACTORS; INFECTION; DISEASE; HHV-6; RECIPIENTS; VIRUS;
Keywords:
cytomegalovirus; human herpesvirus-6; human herpesvirus-7;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Griffiths, PD Royal Free & Univ Coll, Sch Med, Dept Virol, Royal Free Campus,Rowland Hill St, London, England Royal Free & Univ Coll Royal Free Campus,Rowland Hill St London England
Citazione:
P.D. Griffiths et al., "Human herpesviruses 6 and 7 as potential pathogens after liver transplant:Prospective comparison with the effect of cytomegalovirus", J MED VIROL, 59(4), 1999, pp. 496-501

Abstract

Because cytomegalovirus (CMV) is an important opportunistic infection after liver transplant, we conducted a prospective study to see if the same applied to human herpesviruses (HHV)-6 and -7. We used polymerase chain reaction (PCR) methods optimised to detect active, not latent, infection and studied patients not receiving antiviral prophylaxis for CMV. Post-transplant, 536 blood samples were tested by PCR (median 7; range 4-50). Active infection with CMV was detected in 28/60 (47%), HHV-6 in 19/60 (32%), and HHV-7 in29/60 (48%) of patients. The PCR-positive samples were tested by quantitative-competitive PCR to measure the virus load of each betaher-pesvirus. Themedian peak virus load for CMV was significantly greater than that for HHV-6 or HHV-7. Detailed clinicopathological analyses for the whole populationshowed that CMV and HHV-6 were each significantly associated with biopsy-proven graft rejection. Individual case histories suggested that HHV-6 and HHV-7 may be the cause of some episodes of hepatitis and pyrexia. It is concluded that HHV-6 is a previously unrecognized contributor to the morbidity of liver transplantation, that HHV-7 may also be important and that both viruses should be included in the differential diagnosis of graft dysfunction. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:08:17