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Titolo:
Synthesis and evaluation of a new fluorine-18 labeled rotenoid as a potential pet probe of mitochondrial complex I activity.
Autore:
Martarello, L; Greenamyre, JT; Goodman, MM;
Indirizzi:
Emory Univ, Emory Ctr Positron Emiss Tomog, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 sitron Emiss Tomog, Atlanta, GA 30322 USA Emory Univ, Dept Radiol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Univ, Dept Radiol, Atlanta, GA 30322 USA Emory Univ, Dept Neurol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Univ, Dept Neurol, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
fascicolo: 11, volume: 42, anno: 1999,
pagine: 1039 - 1051
SICI:
0362-4803(199911)42:11<1039:SAEOAN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; PARKINSONS-DISEASE; DIHYDROROTENONE BINDING; OXIDATIVE-METABOLISM; H-3 DIHYDROROTENONE; NADH DEHYDROGENASE; PIERICIDIN; INHIBITION; DEFICIENCY;
Keywords:
rotenone; radiofluorine; PET; complex I (NADH : ubiquinone oxidoreductase); Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Martarello, L Emory Univ, Emory Ctr Positron Emiss Tomog, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 omog, Atlanta, GA 30322 USA
Citazione:
L. Martarello et al., "Synthesis and evaluation of a new fluorine-18 labeled rotenoid as a potential pet probe of mitochondrial complex I activity.", J LABEL C R, 42(11), 1999, pp. 1039-1051

Abstract

Fluorine-18 labeled (6aS, 12aS, 5'R)-12-deoxo-6',7'-dihydro-7'-fluororote (F-DDRT), a new potential PET probe of mitochondrial complex I activity, was synthesized. [F-18]-DDRT was prepared with good specific activity by nucleophilic displacement with an overall radiochemical yield of 25% (EOB). Theuptake of [F-18]-DDRT in rat brain and heart was compared with the uptake of another fluorine-18 labeled rotenoid: [F-18]-DHRT. In comparison to [F-18]-DHRT, the brain and heart retention of [F-18]-DDRT were both lower at any point of the study (respectively 0.49 and 2.82% dose/g vs 0.34 and 1.24% dose/g at 60 min post injection).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:03:37