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Titolo:
Novel variants in the promoter region of the CREB gene in schizophrenic patients
Autore:
Kawanishi, Y; Harada, S; Tachikawa, H; Okubo, T; Shiraishi, H;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsuchiura, Ibaraki 3058575, Japan Univ Tsukuba Tsuchiura Ibaraki Japan 3058575 iura, Ibaraki 3058575, Japan Univ Tsukuba, Inst Community Med, Ibaraki, Osaka, Japan Univ Tsukuba Ibaraki Osaka Japan st Community Med, Ibaraki, Osaka, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 6, volume: 44, anno: 1999,
pagine: 428 - 430
SICI:
1434-5161(1999)44:6<428:NVITPR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEMENT-BINDING-PROTEIN; 5-HT1A;
Keywords:
cAMP-responsive element-binding protein; transcription factor; promoter; variant; schizophrenia; clinical characteristics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Kawanishi, Y Univ Tsukuba, Inst Clin Med, Dept Psychiat, 1-1-1 Tennoudai, Tsuchiura, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennoudai Tsuchiura Ibaraki Japan 3058575
Citazione:
Y. Kawanishi et al., "Novel variants in the promoter region of the CREB gene in schizophrenic patients", J HUM GENET, 44(6), 1999, pp. 428-430

Abstract

Cyclic AMP-responsive element-binding protein (CREB) is one of the messenger molecules involved in intracellular signal transduction pathways used bymost dopamine and serotonin receptor subtypes. In addition, CREB stimulates the expression of a number of genes, alterations in the expression of which may be associated with schizophrenia. The promoter region of the human CREB gene was therefore analyzed to identify genetic variants that may lead to the modification of CREB expression and contribute to schizophrenia. Eighty unrelated schizophrenics and 100 healthy controls were screened for genetic variants of the CREB gene by SSCP analysis, followed by direct sequencing of PCR products. Two novel variants (-933T-->C and -413G-->A) were found only in schizophrenics. A patient with the -933T-->C variant had unusual clinical characteristics in addition to typical schizophrenic symptoms.

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Documento generato il 28/01/20 alle ore 15:13:07