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Titolo:
Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines
Autore:
Ariyama, Y; Mori, T; Shinomiya, T; Sakabe, T; Fukuda, Y; Kanamaru, A; Yamada, Y; Isobe, M; Seto, M; Nakamura, Y; Inazawa, J;
Indirizzi:
Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Cytogenet, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Kinki Univ, Sch Med, Dept Internal Med 3, Osaka 589, Japan Kinki Univ Osaka Japan 589 ch Med, Dept Internal Med 3, Osaka 589, Japan Nagasaki Univ Hosp, Dept Clin Lab, Nagasaki, Japan Nagasaki Univ Hosp Nagasaki Japan Hosp, Dept Clin Lab, Nagasaki, Japan Toyama Univ, Sch Technol, Dept Cell Technol, Toyama 930, Japan Toyama Univ Toyama Japan 930 chnol, Dept Cell Technol, Toyama 930, Japan Aichi Canc Ctr Inst, Lab Chemotherapy, Nagoya, Aichi, Japan Aichi Canc CtrInst Nagoya Aichi Japan hemotherapy, Nagoya, Aichi, Japan Univ Tokyo, Ctr Human Genome, Mol Med Lab, Tokyo, Japan Univ Tokyo TokyoJapan kyo, Ctr Human Genome, Mol Med Lab, Tokyo, Japan Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Med, Tokyo, Japan Univ Tokyo Tokyo Japan , Ctr Human Genome, Lab Genome Med, Tokyo, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 6, volume: 44, anno: 1999,
pagine: 357 - 363
SICI:
1434-5161(1999)44:6<357:CIIATL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS TYPE-I; DOUBLE-MINUTE CHROMOSOMES; PROVIRUS GENOME; TCL1 GENE; DNA; TAX; IDENTIFICATION; AMPLIFICATION; MALIGNANCIES; ACTIVATION;
Keywords:
ATL; CGH; 14q32; TCL1; 2p; HTLF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Inazawa, J Tokyo Med & Dent Univ, Med Res Inst, Dept Mol Cytogenet, BunkyoKu, 1-5-45Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138519 Japan
Citazione:
Y. Ariyama et al., "Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines", J HUM GENET, 44(6), 1999, pp. 357-363

Abstract

Comparative genomic hybridization was used to identify chromosomal imbalances in eight cell lines and 12 blood samples from patients with adult T-cell leukemia/lymphoma (ATL). The chromosomes most often over-represented in the cell lines were 2p (6 cases), 7q (4 cases), and 14q (4 cases), with minimal common regions at 2p16-22, 7q21-36, and 14q32, respectively. Distinct imbalances were detected in only 7 of the clinical samples. Chromosomes 14q32 and 2p16-22 harbor TCL1 and a transcription factor, HTLF (human T-cell leukemia virus enhancer factor), respectively. FISH analysis revealed that TCL1 did not juxtapose to TCRA, and we detected no expression of TCL1 in any of the ATL cell lines despite the 14q32 amplifications. Moreover, expression of HTLF was not elevated in the ATL cell lines bearing multiplication of 2p. These results suggest that chromosomal regions 2p16-22 and 14q32 harborgenes other than HTLF and TCL1 that are involved in cellular immortalization or in the pathogenesis of ATL.

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Documento generato il 01/12/20 alle ore 00:43:26