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Titolo:
The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration
Autore:
Cieslewicz, G; Tomkinson, A; Adler, A; Duez, C; Schwarze, J; Takeda, K; Larson, KA; Lee, JJ; Irvin, CG; Gelfand, EW;
Indirizzi:
Natl Jewish Med & Res Ctr, Dept Pediat, Div Basic Sci, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 c Sci, Denver, CO 80206 USA Natl Jewish Med & Res Ctr, Dept Med, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 t Med, Denver, CO 80206 USA Mayo Clin Scottsdale, Dept Biochem & Mol Biol, Scottsdale, AZ 85259 USA Mayo Clin Scottsdale Scottsdale AZ USA 85259 ol, Scottsdale, AZ 85259 USA
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 3, volume: 104, anno: 1999,
pagine: 301 - 308
SICI:
0021-9738(199908)104:3<301:TLBNEA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE-PHASE BRONCHOCONSTRICTION; NONANESTHETIZED GUINEA-PIGS; AIRWAY HYPERRESPONSIVENESS; BRONCHOALVEOLAR LAVAGE; ALLERGEN CHALLENGE; MURINE MODEL; BRONCHIAL RESPONSIVENESS; LEUKOCYTE INFILTRATION; ATOPIC ASTHMA; ANIMAL-MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Gelfand, EW Natl Jewish Med & Res Ctr, Dept Pediat, Div Basic Sci, 1400 Jackson St, Denver, CO 80206 USA Natl Jewish Med & Res Ctr 1400 Jackson St Denver CO USA 80206
Citazione:
G. Cieslewicz et al., "The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration", J CLIN INV, 104(3), 1999, pp. 301-308

Abstract

Early-phase reactions (EPRs) and late-phase reactions (LPRs) are characteristic features of bronchial asthma, although the pathogenetic mechanisms responsible for each of the responses are not fully defined. A murine model of EPRs and LPRs was developed to investigate the role of IL-5 and eosinophils in development of both responses. After initial intraperitoneal sensitization and airway challenge to ovalbumin (OVA), mice were provoked by additional exposure to OVA. An EPR, characterized by a transient increase in airway responsiveness, was observed 5-30 minutes after antigen provocation. This response was followed by an LPR that reached its maximum at 6 hours afterchallenge and was characterized by increased airway responsiveness and significant lung eosinophilia. The EPR was blocked by cromoglycate and albuterol, whereas the LPR was abolished by cromoglycate and hydrocortisone. Before provocation with allergen, administration of anti-IL-5 antibody preventedthe influx of eosinophils into the lung tissue and abolished the LPR but not EPR. These results suggest that IL-5 and eosinophils are essential for development of the LPR, but not EPR, in this model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:21:45