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Titolo:
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog
Autore:
Sato, N; Leopold, PL; Crystal, RG;
Indirizzi:
Cornell Univ, New York Presbyterian Hosp, Weill Med Coll, Div Pulm & Crit Care Med, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Crit Care Med, New York, NY 10021 USA
Titolo Testata:
JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 7, volume: 104, anno: 1999,
pagine: 855 - 864
SICI:
0021-9738(199910)104:7<855:IOTHGP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL-CELL CARCINOMA; MOUSE PATCHED GENE; REPLICATION-DEFICIENT; POLARIZING ACTIVITY; SIGNALING PATHWAY; CYSTIC-FIBROSIS; FLOOR PLATE; FOLLICLE; SKIN; MORPHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Crystal, RG Cornell Univ, New York Presbyterian Hosp, Weill Med Coll, Div Pulm & Crit Care Med, 520 E 70th St,ST 505, New York, NY 10021 USA Cornell Univ 520 E 70th St,ST 505 New York NY USA 10021 21 USA
Citazione:
N. Sato et al., "Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog", J CLIN INV, 104(7), 1999, pp. 855-864

Abstract

Hair follicles form in prenatal skin and mature in the postnatal period, establishing a growth cycle in 3 phases: telogen (resting), anagen (growth),and catagen (regression). Based on the knowledge that Sonic hedgehog (Shh)expression is necessary for the embryonic development of hair follicles, and that anagen in the postnatal cycling follicle has morphologic similarities to the epithelial invagination process in embryonic skin, we hypothesized that localized, but transient, enhanced expression of the Shh gene in postnatal skin would accelerate initiation of anagen in the hair follicle cycle, with concomitant accelerated hair growth. To assess this concept, an E1(-) adenovirus vector, AdShh, was used to transfer the murine Shh cDNA to skin of postnatal day 19 C57BL/6 mice. The treated skin showed increased mRNAexpression of Shh, Patched (the Shh receptor), and Gli1 (a transcription factor in the Shh pathway). In mice receiving AdShh, but not in controls, acceleration into anagen was evident, since hair follicle size and melanogenesis increased and the hair-specific keratin ghHb-1 and the melanin synthesis-related tyrosinase mRNAs accumulated. Finally, C57BL/6 mice showed markedacceleration of the onset of new hair growth in the region of AdShh administration to skin 2 weeks after treatment, but not in control vector-treatedor untreated areas. After 6 months, AdShh-treated skin showed normal hair and normal skin morphology. Together, these observations are consistent with the concept that upregulation of Shh activity in postnatal skin functionsas a biologic switch that induces resting hair follicles to enter anagen with consequent hair growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 00:03:20