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Titolo:
Lack of efficacy of the 5-HT3 receptor antagonist granisetron in the treatment of acute neuroleptic-induced akathisia
Autore:
Poyurovsky, M; Weizman, A;
Indirizzi:
Geha Psychiat Hosp, Res Unit, IL-49100 Petah Tiqwa, Israel Geha Psychiat Hosp Petah Tiqwa Israel IL-49100 49100 Petah Tiqwa, Israel Tirat Carmel Mental Hlth Ctr, Res Unit, Tirat Carmel, Israel Tirat Carmel Mental Hlth Ctr Tirat Carmel Israel , Tirat Carmel, Israel Technion Israel Inst Technol, Fac Med, Haifa, Israel Technion Israel Inst Technol Haifa Israel chnol, Fac Med, Haifa, Israel Felsenstein Med Res Ctr, Lab Biol Psychiat, Petah Tiqwa, Israel Felsenstein Med Res Ctr Petah Tiqwa Israel sychiat, Petah Tiqwa, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 6, volume: 14, anno: 1999,
pagine: 357 - 360
SICI:
0268-1315(199911)14:6<357:LOEOT5>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONDANSETRON; CLOZAPINE; MIANSERIN; HALOPERIDOL; COMBINATION; THERAPY;
Keywords:
neuroleptic-induced akathisia; serotonergic system; 5-HT3; antagonist; granisetron;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Weizman, A Geha Psychiat Hosp, Res Unit, POB 102, IL-49100 Petah Tiqwa, Israel Geha Psychiat Hosp POB 102 Petah Tiqwa Israel IL-49100 Israel
Citazione:
M. Poyurovsky e A. Weizman, "Lack of efficacy of the 5-HT3 receptor antagonist granisetron in the treatment of acute neuroleptic-induced akathisia", INT CLIN PS, 14(6), 1999, pp. 357-360

Abstract

The specific mechanism underlying the apparent involvement of the serotonergic (5-HT) system in the pathophysiology of extrapyramidal side-effects, particularly neuroleptic-induced akathisia (NIA), remains unknown. We hypothesized that the 5-HT3 receptor subtype may play a role in the light of the moderate-to-high affinity to this receptor of some of the atypical antipsychotic agents which have a low propensity to cause akathisia, as well as ourearlier findings with the 5-HT2/5-HT3 antagonist mianserin. In an open-label pilot study, we administered the selective 5-HT3 antagonist granisetron (fixed dose, 2 mg/day) for 4 days to 10 neuroleptic-treated patients with acute NIA Three patients discontinued granisetron because of a lack of response. The remainder showed no significant change in score on the Barnes Akathisia Scale during the trial. NIA symptoms remained unchanged or worsened in five patients (71.4%) and improved to a certain degree in only two. It seems that the 5-MT3, subtype of serotonergic receptor is not involved in thedevelopment of NIA, and 5-HT3 antagonists are ineffective in the serotonin-related pharmacotherapy of NIA. Int Clin Psychopharmacol 14:357-360 (C) 1999 Lippincott Williams and Wilkins.

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Documento generato il 19/01/20 alle ore 09:12:27