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Titolo:
Fluoxetine versus amitriptyline in the treatment of major depression with associated anxiety (anxious depression): a double-blind comparison
Autore:
Versiani, M; Ontiveros, A; Mazzotti, G; Ospina, J; Davila, J; Mata, S; Pacheco, A; Plewes, J; Tamura, R; Palacios, M;
Indirizzi:
Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA Lilly Corp CtrIndianapolis IN USA 46285 Labs, Indianapolis, IN 46285 USA
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 6, volume: 14, anno: 1999,
pagine: 321 - 327
SICI:
0268-1315(199911)14:6<321:FVAITT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTROLLED CLINICAL-TRIAL; FOLLOW-UP; DISORDERS; FAMILY; DIFFERENTIATION; OUTPATIENTS; STATES;
Keywords:
amitriptyline; fluoxetine; anxious depression; major depression; anxiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Plewes, J Lilly Corp Ctr, Lilly Res Labs, Drop Code 2032, Indianapolis, IN46285 USA Lilly Corp Ctr Drop Code 2032 Indianapolis IN USA 46285 6285 USA
Citazione:
M. Versiani et al., "Fluoxetine versus amitriptyline in the treatment of major depression with associated anxiety (anxious depression): a double-blind comparison", INT CLIN PS, 14(6), 1999, pp. 321-327

Abstract

Although common in clinical settings, major depressive disorder with associated anxious symptoms ('anxious depression') has not been well studied in antidepressant clinical trials. The aim of this study was to compare the effects of fluoxetine versus amitriptyline in this group of patients. After asingle-blind placebo run-in period of 2 weeks, patients were treated on a double-blind basis with fluoxetine or amitriptyline for 8 weeks. Assessmentinstruments included: 21-item Hamilton Rating Scale for Depression, Hamilton Rating Scale for Anxiety, Clinical Global Impressions, Raskin DepressionScale and Covi Anxiety Scale. A total of 157 patients were randomized to either fluoxetine or amitriptyline. Fluoxetine was given at a fixed dose of 20 mg/day and amitriptyline was given in a range of 50-250 mg/day (mean of 138.1 mg/day). Fluoxetine was comparable to amitriptyline in all efficacy measures except the HAMD sleep factor. Unwanted effects were more frequent and more severe in the amitriptyline-treated patients. Fluoxetine was comparably efficacious to amitriptyline in the treatment of major depression withassociated anxiety. Since fluoxetine was far better tolerated, it is a promising alternative for this frequent and disabling condition. Int Clin Psychopharmacol 14:321-327 (C) 1999 Lippincott Williams & Wilkins.

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Documento generato il 03/04/20 alle ore 10:03:36