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Titolo:
Outcome of de novo hepatitis C virus infection in heart transplant recipients
Autore:
Ong, JP; Barnes, DS; Younossi, ZM; Gramlich, T; Yen-Lieberman, B; Goormastic, M; Sheffield, C; Hoercher, K; Starling, R; Young, J; Smedira, N; McCarthy, P;
Indirizzi:
Cleveland Clin Fdn, Dept Gastroenterol 540, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ol 540, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Lab Med & Microbiol, Cleveland, OH 44195 USA ClevelandClin Fdn Cleveland OH USA 44195 robiol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Cardiothorac Surg, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 c Surg, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Cardiol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ardiol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Ctr Transplant, Cleveland, OH 44195 USA Cleveland ClinFdn Cleveland OH USA 44195 splant, Cleveland, OH 44195 USA
Titolo Testata:
HEPATOLOGY
fascicolo: 5, volume: 30, anno: 1999,
pagine: 1293 - 1298
SICI:
0270-9139(199911)30:5<1293:OODNHC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-TRANSPLANTATION; CHOLESTATIC HEPATITIS; ORGAN-TRANSPLANTATION; VIRAL-INFECTION; TRANSMISSION; DONORS; CANDIDATES; PREVALENCE; GENOTYPES; SEVERITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Barnes, DS Cleveland Clin Fdn, Dept Gastroenterol 540, Cleveland, OH 44195USA Cleveland Clin Fdn Cleveland OH USA 44195 veland, OH 44195 USA
Citazione:
J.P. Ong et al., "Outcome of de novo hepatitis C virus infection in heart transplant recipients", HEPATOLOGY, 30(5), 1999, pp. 1293-1298

Abstract

The outcome of de novo hepatitis C virus (HCV) infection in heart transplant recipients of HCV-antibody positive organs is not known. The aim of the study was to determine the short-term outcome of de novo HCV infection in recipients of HCV-positive donor organs. HCV-antibody negative recipients ofHCV-antibody positive hearts were identified from January 1, 1991 to February 28, 1998. Control patients matched for year of transplantation were also identified. Twenty-eight patients (22 males, mean age of 56 +/- 11 SD) received hearts from HCV-antibody-positive donors. The control group was similar to the patients in all clinical and demographic aspects. Twenty-three patients had detectable viremia by reverse-transcription polymerase chain reaction (RT-PCR). Of these 23 patients with de novo HCV infection, 7 (30%) developed HCV-related liver disease. Three patients (13%) had chronic hepatitis and 4 patients (17%) developed severe acute cholestatic hepatitis (ACH), Mycophenolate mofetil (MMF) use (P = .04) and high viral load at onset ofacute liver disease (P = .02) were associated with AGH. Overall survival was similar between patients with de novo HCV infection and controls (P = .20). Development of ACH (P = .02) and MMF use (P = .0009) were associated with decreased survival in patients with de novo HCV infection. The present study showed that survival of patients with de novo HCV infection was similar tot a matched control group. HCV-related severe ACH is associated with a poor short-term outcome in patients with de novo HCV infection. MMF use maybe associated with a higher incidence of HCV-related severe ACH and a poorshort-term outcome.

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Documento generato il 18/09/20 alle ore 11:15:52