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Titolo:
Lung cancer risk in families of nonsmoking probands: Heterogeneity by age at diagnosis
Autore:
Yang, P; Schwartz, AG; McAllister, AE; Swanson, GM; Aston, CE;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA Mayo Clin& Mayo Fdn Rochester MN USA 55905 Res, Rochester, MN 55905 USA Allegheny Univ Hlth Sci, MCP Hahnemann Sch Med, Pittsburgh, PA USA Allegheny Univ Hlth Sci Pittsburgh PA USA nn Sch Med, Pittsburgh, PA USA Univ Pittsburgh, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USAUniv Pittsburgh, Pittsburgh, PA USA Michigan State Univ, Ctr Canc, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 Canc, E Lansing, MI 48824 USA Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 n Med, E Lansing, MI 48824 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
fascicolo: 4, volume: 17, anno: 1999,
pagine: 253 - 273
SICI:
0741-0395(1999)17:4<253:LCRIFO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; GENETIC EPIDEMIOLOGY; SEGREGATION ANALYSIS; RESPIRATORY-DISEASE; HISTORY; SMOKING; RELATIVES; POLYMORPHISM; TRANSFERASE; ASSOCIATION;
Keywords:
chronic lung diseases; familial aggregation; lung cancer; Mendelian inheritance; tobacco exposure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, P Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, 200 1st St SW, Rochester,MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 5905 USA
Citazione:
P. Yang et al., "Lung cancer risk in families of nonsmoking probands: Heterogeneity by age at diagnosis", GENET EPID, 17(4), 1999, pp. 253-273

Abstract

In an earlier investigation, we did not detect a major genetic component to lung cancer in families of nonsmoking lung cancer probands. However, heterogeneity with respect to familial aggregation, based on probands' age at diagnosis, was evident. We reanalyzed our previously collected data of 257 families, stratified by age at diagnosis of the probands, using complex segregation analysis. We specifically tested the effects of a Mendelian diallelic gene, history of tobacco use, and history of selected chronic lung diseases in families with a proband diagnosed at the age of 60 years or older and in families with a younger proband (i.e., under 60 years of age). Cases were identified from the Metropolitan Detroit Cancer Surveillance System. Information an lung cancer occurrence, smoking history, and chronic respiratory diseases in first-degree relatives was obtained for 210 older probands and for 47 younger probands. In older probands' families, no evidence of a major genetic effect was detected. A history of emphysema and tobacco-smoke exposure were found to be significant risk factors. In younger probands' families, a Mendelian codominant model. with significant modifying effects ofsmoking and chronic bronchitis best explained the observed data. Our results suggest the presence of a high-risk gene contributing to early-onset lung cancer in a population where the probands are nonsmokers. Genet. Epidemiol. 17:253-273, 1999. (C) 1999 Wiley-Liss,Inc.

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Documento generato il 08/07/20 alle ore 07:35:23