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Titolo:
Physicochemical characterization of MS-325, a new gadolinium complex, by multinuclear relaxometry
Autore:
Muller, RN; Raduchel, B; Laurent, S; Platzek, J; Pierart, C; Mareski, P; Vander Elst, L;
Indirizzi:
Univ Mons, NMR Lab, Dept Organ Chem, B-7000 Mons, Belgium Univ Mons MonsBelgium B-7000 Lab, Dept Organ Chem, B-7000 Mons, Belgium Schering AG, Res Labs, D-13342 Berlin, Germany Schering AG Berlin Germany D-13342 AG, Res Labs, D-13342 Berlin, Germany
Titolo Testata:
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
fascicolo: 11, , anno: 1999,
pagine: 1949 - 1955
SICI:
1434-1948(199911):11<1949:PCOMAN>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE ANGIOGRAPHY; INTRAVASCULAR CONTRAST AGENT; MR-ANGIOGRAPHY; COORDINATED WATER; O-17 NMR; EXCHANGE; RELAXATION; DIFFUSION; STABILITY; PROTONS;
Keywords:
MS-325; angiography; MRI contrast agent; NMR spectroscopy; interaction with HSA; gadolimium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, RN Univ Mons, NMR Lab, Dept Organ Chem, B-7000 Mons, Belgium Univ Mons Mons Belgium B-7000 rgan Chem, B-7000 Mons, Belgium
Citazione:
R.N. Muller et al., "Physicochemical characterization of MS-325, a new gadolinium complex, by multinuclear relaxometry", EUR J INORG, (11), 1999, pp. 1949-1955

Abstract

The physicochemical characterization of MS-325 [trisodium {4 (R)-[(4,4-diphenylcyclohexyl)phosphanooxymethyl]-3,6,9-tri aza-3,6,9-tris(methoxycarbonyl)undecanedioato}gadolinium-(III)] new derivative of Gd-DTPA {Magnevist(R):dimeglumin [(3,6,9-triaza3,6,9-tris(methoxycarbonyl oato}gadolinium(III)],presented as a potentially useful angiographic contrast agent, was carriedout in various media. Water solution, protein-containing solution, phosphorylated metabolites solution, and Zn2+-containing solution were investigated using different NMR techniques such as water H-1 nuclear magnetic relaxation rates, water O-17 transverse relaxation rates, and P-31 longitudinal relaxation rates of phosphorylated metabolites. The proton relaxivity of MS-325 in water was found to be higher than that of the parent compound Gd-DTPA; this can be attributed to the longer rotational correlation time (tau(R))Of the hydrated complex, and possibly to an apparently shorter mean distance (r) between the protons of the coordinated water molecule and the gadolinium ion. The kinetic and thermodynamic stability of MS-325 in solutions containing phosphorylated metabolites (ATP, phosphocreatine and inorganic phosphate) were measured by P-31 relaxation rate analysis and found to be higher than for Gd-DTPA. Similarly, the Zn2+ transmetallation process studied by proton relaxometry is slower than for the same reference compound. Finally, an analysis of the noncovalent binding of MS-325 to serum proteins by proton relaxometry showed that MS-325 interacts with human serum albumin (HSA) and that the association constant of this interaction is equal to 6100 +/- 2130 M-1. A peak relaxivity of approx. 50 s(-1)mM(-1) was determined at 25 MHz for the protein-bound paramagnetic complex. This value is lower than the maximal relaxivity predicted for a paramagnetic center totally immobilized at the surface of the protein.

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Documento generato il 23/09/20 alle ore 06:30:52