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Titolo:
Endocrine regulation of neurotransmitter transporters
Autore:
Figlewicz, DP;
Indirizzi:
Univ Washington, Dept Psychol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Psychol, Seattle, WA 98195 USA Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA
Titolo Testata:
EPILEPSY RESEARCH
fascicolo: 3, volume: 37, anno: 1999,
pagine: 203 - 210
SICI:
0920-1211(199912)37:3<203:ERONT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN DOPAMINE TRANSPORTER; BRAIN GABA TRANSPORTER; MESSENGER-RNA; RAT-BRAIN; SEROTONIN TRANSPORTERS; NOREPINEPHRINE UPTAKE; FUNCTIONAL REGULATION; TYROSINE-HYDROXYLASE; EXPRESSION CLONING; NEURONAL CULTURES;
Keywords:
insulin; glucocorticoids; transporters; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Figlewicz, DP VA Puget Sound Hlth Care Syst, Dept Metab Endocrinol, 151,1660 So Columbian Way, Seattle, WA 98108 USA VA Puget Sound Hlth Care Syst 151,1660 So Columbian Way Seattle WA USA 98108
Citazione:
D.P. Figlewicz, "Endocrine regulation of neurotransmitter transporters", EPILEPSY R, 37(3), 1999, pp. 203-210

Abstract

Aminergic signalling in the CNS is terminated by clearance of neurotransmitters from the synapse via high affinity transporter molecules in the presynaptic membrane. Relatively recent sequence identification of these molecules has now permitted the initiation of studies of regulation of transporterfunction at the cellular and systems levels. In vitro studies provide evidence that the transporters for dopamine, serotonin, and gamma-aminobutyric acid (GABA) may be substrates for regulation by protein kinase C and protein kinase A signalling. Changes in energy balance and metabolic status, suchas starvation, result in major shifts in hormonal output. It is now recognized that metabolic hormones such as insulin or the adrenal steroids can have significant acute and chronic effects on several aspects of CNS function. Data from this laboratory and others now provide evidence that insulin and adrenal and gonadal steroid hormones may regulate the synthesis and activity of the transporters. Future studies should permit elucidation of the cellular basis for endocrine regulation of neurotransmitter clearance, and thus, the role of endocrines in the maintenance of normal CNS aminergic signalling. The potential relevance of transporter regulation for the ketogenic diet is discussed. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 03/04/20 alle ore 13:54:37