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Titolo:
Assessment of vascular maturation in non-small cell lung cancer using a novel basement membrane component, LH39: Correlation with p53 and angiogenic factor expression
Autore:
Kakolyris, S; Giatromanolaki, A; Koukourakis, M; Leigh, IM; Georgoulias, V; Kanavaros, P; Sivridis, E; Gatter, KC; Harris, AL;
Indirizzi:
Univ Hosp Heraklion, Dept Clin Oncol, Tumor & Angiogenesis Res Grp, Heraklion 71110, Crete, Greece Univ Hosp Heraklion Heraklion Crete Greece 71110 ion 71110, Crete, Greece Univ Hosp Heraklion, Dept Radiotherapy, Heraklion 71110, Crete, Greece Univ Hosp Heraklion Heraklion Crete Greece 71110 ion 71110, Crete, Greece Univ Hosp Heraklion, Dept Pathol, Heraklion 71110, Crete, Greece Univ HospHeraklion Heraklion Crete Greece 71110 ion 71110, Crete, Greece Democritus Univ Thrace, Dept Histopathol, Alexandroupolis, Thrace, Greece Democritus Univ Thrace Alexandroupolis Thrace Greece lis, Thrace, Greece Royal London Hosp, Expt Dermatol Lab, London E1 1BB, England Royal London Hosp London England E1 1BB atol Lab, London E1 1BB, England Univ Oxford, John Radcliffe Hosp, Dept Cellular Sci, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU Cellular Sci, Oxford OX3 9DU, England Univ Oxford, John Radcliffe Hosp, Imperial Canc Res Fund, Mol Oncol Lab, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ol Oncol Lab, Oxford OX3 9DU, England
Titolo Testata:
CANCER RESEARCH
fascicolo: 21, volume: 59, anno: 1999,
pagine: 5602 - 5607
SICI:
0008-5472(19991101)59:21<5602:AOVMIN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR THYMIDINE PHOSPHORYLASE; TUMOR-RELATED ANGIOGENESIS; ENDOTHELIAL GROWTH-FACTOR; PROGNOSTIC VALUE; INHIBITION; PEPTIDE; LAMININ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kakolyris, S Univ Hosp Heraklion, Dept Clin Oncol, Tumor & Angiogenesis Res Grp, POB 1352, Heraklion 71110, Crete, Greece Univ Hosp Heraklion POB 1352 Heraklion Crete Greece 71110 ece
Citazione:
S. Kakolyris et al., "Assessment of vascular maturation in non-small cell lung cancer using a novel basement membrane component, LH39: Correlation with p53 and angiogenic factor expression", CANCER RES, 59(21), 1999, pp. 5602-5607

Abstract

Angiogenesis, the formation of new vessels, has been demonstrated to be a potent and independent indicator of prognosis in non-small cell lung cancerpatients. The extent of differentiation of the tumor vessels may affect access of peripheral white cells and egress or invasion of tumor cells. This has not been assessed in relation to tumor microvessel density or other variables and may be a marker of vascular remodeling, LH39 is a monoclonal antibody recognizing an epitope located at the lamina lucida of mature small veins and capillaries but not in newly formed vessels. Rie examined the ratio of mature:immature vessels in 81 non-small cell lung carcinomas and correlated the vascular maturation index (VMI) to different clinicopathological variables including angiogenesis, Mature vessels were defined by staining with. antibodies to both LH39 and to CD31, using double immunohistochemistry, whereas immature vessels stained only for CD31, VMI was defined as the percentage fraction of mature vessels (LH39 positive)/total number of vessels(CD31 positive). The median VMI in lung carcinomas was 46% (range, 15-90%), There was a significant inverse correlation between high VMI and low thymidine phosphorylase expression (P = 0.0001), high VMI and nuclear p53 negativity (P = 0.01), high VMI and low angiogenesis (P = 0.0001), as well as between high VMI and absence of nodal involvement (P = 0.01). Low angiogenesis and high VMI were associated with a significantly better outcome (P = 0.0001 and P = 0.02, respectively), These findings show that there is a wide variation in the differentiation of tumor vasculature in lung carcinomas, and VMI gives new information on the degree of active tumor vascular remodeling independently from microvessel quantitation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:09:13