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Titolo:
Positron emission tomography of esophageal carcinoma using C-11-choline and F-18-fluorodeoxyglucose - A novel method of preoperative lymph node staging
Autore:
Kobori, D; Kirihara, Y; Kosaka, N; Hara, T;
Indirizzi:
Int Med Ctr Japan, Dept Radiol, Shinjuku Ku, Tokyo 162, Japan Int Med Ctr Japan Tokyo Japan 162 Radiol, Shinjuku Ku, Tokyo 162, Japan Int Med Ctr Japan, Dept Surg, Tokyo, Japan Int Med Ctr Japan Tokyo Japan nt Med Ctr Japan, Dept Surg, Tokyo, Japan
Titolo Testata:
CANCER
fascicolo: 9, volume: 86, anno: 1999,
pagine: 1638 - 1648
SICI:
0008-543X(19991101)86:9<1638:PETOEC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; CHOLINE KINASE-ACTIVITY; BREAST-CANCER CELLS; TRANSHIATAL ESOPHAGECTOMY; TUMOR; METABOLISM; CT; ENDOSONOGRAPHY; THORACOTOMY; FDG;
Keywords:
esophagus; carcinoma; diagnosis; staging; lymph node; positron emission tomography; C-11-choline; F-18-fluorodeoxyglucose;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Hara, T Int Med Ctr Japan, Dept Radiol, Shinjuku Ku, 1-21-1 Toyama, Tokyo 162, Japan Int Med Ctr Japan 1-21-1 Toyama Tokyo Japan 162 Tokyo 162, Japan
Citazione:
D. Kobori et al., "Positron emission tomography of esophageal carcinoma using C-11-choline and F-18-fluorodeoxyglucose - A novel method of preoperative lymph node staging", CANCER, 86(9), 1999, pp. 1638-1648

Abstract

BACKGROUND, Accurate preoperative staging is an important but difficult problem in determining therapy for patients with esophageal carcinoma. Positron emission tomography (PET) is used with [methyl-C-11]choline (C-11-choline) and 2-[F-18]fluoro-2-deoxy-D-glucose (F-18-FDG) to detect a variety of malignancies. The authors used PET with both of these agents to detect lymphnode metastases in patients with esophageal carcinoma. METHODS, Lymph node metastases in 33 patients with biopsy-proven esophageal carcinoma (16 patients with tumors classified as T1 and 17 patients with tumors classified as T2-4) was examined by PET using C-11-choline and F-18-FDG, and the accuracy of the results was correlated with pathology findingsafter surgery. RESULTS. C-11-choline PET was more effective than F-18-FDG PET and computed tomography (CT) in detecting very small metastases localized in the mediastinum. It was ineffective, however, in detecting metastases localized in the upper abdomen, because of the normal uptake of C-11-choline in the liver, F-18-FDG PET was superior to CT in detecting metastases in the mediastinum and the upper abdomen, whereas C-11-choline PET was superior to F-18-FDG PET in detecting metastases in the mediastinum. When C-11-choline PET and F-18-FDG PET were used in combination, they were very effective in evaluating the lymph node status in both the mediastinum and the upper abdomen, and detected 85% of the metastatic lymph nodes (n = 46). CONCLUSIONS. In this study, the combination of C-11-choline PET and F-18-FDG PET was very effective in evaluating the lymph node status of patients with esophageal carcinoma preoperatively. (C) 1999 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:22:39