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Titolo:
Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder
Autore:
Southwick, SM; Bremner, JD; Rasmusson, A; Morgan, CA; Arnsten, A; Charney, DS;
Indirizzi:
Dept Vet Affairs Med Ctr, Dept Psychiat 116A, Natl Ctr PTSD, Clin NeurosciDiv, W Haven, CT 06516 USA Dept Vet Affairs Med Ctr W Haven CT USA 06516 iDiv, W Haven, CT 06516 USA Yale Univ, Sch Med, New Haven, CT USA Yale Univ New Haven CT USAYale Univ, Sch Med, New Haven, CT USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 9, volume: 46, anno: 1999,
pagine: 1192 - 1204
SICI:
0006-3223(19991101)46:9<1192:RONITP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; LOCUS COERULEUS NEURONS; PLASMA NOREPINEPHRINE; CEREBROSPINAL-FLUID; COGNITIVE FUNCTION; ANXIETY DISORDERS; VIETNAM VETERANS; EMOTIONAL EVENTS; MEMORY RETRIEVAL; NEUROPEPTIDE-Y;
Keywords:
norepinephrine; posttraumatic stress disorder; arousal; memory; psychopharmacology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Southwick, SM Dept Vet Affairs Med Ctr, Dept Psychiat 116A, Natl Ctr PTSD,Clin NeurosciDiv, 950 Campbell Ave, W Haven, CT 06516 USA Dept Vet AffairsMed Ctr 950 Campbell Ave W Haven CT USA 06516
Citazione:
S.M. Southwick et al., "Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder", BIOL PSYCHI, 46(9), 1999, pp. 1192-1204

Abstract

This review focuses on the role of norepinephrine (NE) in traumatic stress, The review is divided into three sections. The first section, "Norepinephrine and Arousal" describes pr preclinical studies related to norepinephrine's role in arousal, orienting to novel stimuli, selective attention and vigilance, It also contains a brief discussion of NE and its relationship to fear-provoking stimuli followed by preclinical and clinical studies that demonstrate heightened noradrenergic neuronal reactivity, increased alpha(2) receptor sensitivity and exaggerated arousal in organisms that have been exposed to chronic uncontrollable stress. The second section, "Norepinephrineand Memory," describes preclinical and clinical studies related to norepinephrine's role in enhanced encoding of memory fbr arousing and aversive events and in subsequent re-experiencing symptoms such as, intrusive memories and nightmares, The third section, "Norepinephrine and Pharmacologic Treatment," briefly discusses the use of adrenergic blockers, clonidine and propranol, as well as tricyclic and MAO inhibitors, for the treatment of PTSD. Finally, we attempt to synthesize trauma-related preclinical and clinical studies of norepinephrine. We do this, in part, by focusing on a series of yohimbine studies in subjects with PTSD because data from these studies allowfor a discussion that brings together preclinical and clinical findings relevant to trauma-related alterations in arousal and memory. (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:49:00