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Titolo:
Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy
Autore:
Sanacora, G; Mason, GF; Rothman, DL; Behar, KL; Hyder, F; Petroff, OAC; Berman, RM; Charney, DS; Krystal, JH;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ, Sch Med, Dept Biomed Engn, New Haven, CT USA Yale Univ New Haven CT USA Sch Med, Dept Biomed Engn, New Haven, CT USA Yale Univ, Sch Med, Dept Radiol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ed, Dept Radiol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ed, Dept Neurol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Mol Biophys & Biochem, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 ophys & Biochem, New Haven, CT 06510 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 11, volume: 56, anno: 1999,
pagine: 1043 - 1047
SICI:
0003-990X(199911)56:11<1043:RCGALI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; PSYCHIATRIC-DISORDERS; LEARNED HELPLESSNESS; MOOD DISORDERS; GABA LEVEL; GLUTAMATE; EPILEPSY; CSF; RECEPTORS; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sanacora, G Connecticut Mental Hlth Ctr, Clin Neurosci Res Unit, Abraham Ribicoff Res Facil, 34 Pk St, New Haven, CT 06519 USA Connecticut Mental Hlth Ctr 34 Pk St New Haven CT USA 06519 SA
Citazione:
G. Sanacora et al., "Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy", ARCH G PSYC, 56(11), 1999, pp. 1043-1047

Abstract

Background: Several lines of emerging evidence suggest that dysfunction ofgamma-aminobutyric acid (GABA) systems is associated with major depression. However, investigation of this hypothesis is limited by difficulty obtaining noninvasive in vivo measures of brain GABA levels. In this study we used in vivo proton magnetic resonance spectroscopy to investigate the hypothesis that abnormalities in the GABA neurotransmitter system are associated with the neurobiologic processes of depression. Methods: The GABA levels were measured in the occipital cortex of medication-free depressed patients meeting DSM-IV criteria (n = 14) and healthy control subjects with no history of mental illness (n = 18) using a localized difference editing proton magneticresonance spectroscopy protocol. An analysis of covariance was employed to examine the effects of depression, sex, and age. Results: The depressed patients demonstrated a highly significant (52%) reduction in occipital cortex GABA levels compared with the group of healthy subjects. While there were significant age and sex effects, there was no interaction of diagnosis with either age or sex. Conclusion: This study provides the first evidence of abnormally low cortical GABA concentrations in the brains of depressed patients.

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Documento generato il 18/01/20 alle ore 13:48:58