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Titolo:
Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas
Autore:
Wilentz, RE; Albores-Saavedra, J; Zahurak, M; Talamini, MA; Yeo, CJ; Cameron, JL; Hruban, RH;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Oncol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 t Surg, Baltimore, MD 21205 USA Univ Texas, SW Med Sch, Dept Pathol, Dallas, TX USA Univ Texas Dallas TX USA Texas, SW Med Sch, Dept Pathol, Dallas, TX USA
Titolo Testata:
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
fascicolo: 11, volume: 23, anno: 1999,
pagine: 1320 - 1327
SICI:
0147-5185(199911)23:11<1320:PEAPPI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAS ONCOGENE MUTATIONS; LATENT MALIGNANCY; CYSTADENOCARCINOMA; CYSTADENOMA; TUMORS; EXPRESSION; LESIONS;
Keywords:
pancreas; mucinous cystic neoplasm; mucinous cystadenoma; invasive mucinous cystadenocarcinoma; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Hruban, RH Johns Hopkins Hosp, Dept Pathol, Meyer 7-181,600 N Wolfe St, Baltimore, MD21287 USA Johns Hopkins Hosp Meyer 7-181,600 N Wolfe St Baltimore MD USA 21287
Citazione:
R.E. Wilentz et al., "Pathologic examination accurately predicts prognosis in mucinous cystic neoplasms of the pancreas", AM J SURG P, 23(11), 1999, pp. 1320-1327

Abstract

The behavior of pancreatic mucinous cystic neoplasms has long been debated. Some authors contend that histologically benign neoplasms can recur and metastasize. We reviewed the grass and microscopic findings and outcomes of 61 mucinous cystic neoplasms diagnosed at The Johns Hopkins Hospital from March 20, 1984 to July 8, 1998. Each neoplasm was placed into one of four categories based on complete histologic examination: invasive mucinous cystadenocarcinoma, mucinous cystic neoplasm with in situ carcinoma,borderline mucinous cystic neoplasm, and mucinous cystadenoma. Neoplasms in the latter three categories were included only if they were entirely resected and completely examined. Patient outcomes were obtained from hospital records and patient and physician followup. Twenty (33%) of the patients had invasive mucinous cystadenocarcinomas, and they had 2- and 5-year disease-specific survival rates of 67% and 33% (mean follow-up of survivors, 4.2 years), respectively. Nine (15%) patients had mucinous cystic neoplasms with in situ carcinoma (mean follow-up of survivors, 4.1 years). Five (8.2%) patients bad borderline mucinous cystic neoplasms (mean follow-up of survivors, 5.6 years). Twenty-seven (44%) patients bad mucinous cystadenomas (mean follow-up of survivors,5.1 years). No mucinous cystadenoma, borderline mucinous cystic neoplasm, or mucinous cystic neoplasm with in situ carcinoma recurred or metastasized, No patient with the diagnosis of mucinous cystadenoma, borderlinemucinous cystic neoplasm, or mucinous cystic neoplasm with in situ carcinoma died of disease. The difference in disease-specific survival rates between patients with invasive mucinous cystadenocarcinomas and those with noninvasive tumors was significant (p < 0.0001, log-rank test). One case, originally showing only benign histology on incisional biopsy, contained foci of invasive carcinoma on complete resection. Completely resected and entirely examined mucinous cystadenomas, borderline mucinous cystic neoplasms, and mucinous cystic neoplasms with in situ carcinoma follow benign courses. Because invasive carcinoma can be focal, failure to study an entire mucinous cystic neoplasm may result in the miscategorization of a malignant neoplasm as benign.

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Documento generato il 26/11/20 alle ore 14:23:59