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Titolo:
The possible role of antiovary antibodies in repeated in vitro fertilization failures
Autore:
Geva, E; Fait, G; Lerner-Geva, L; Lessing, JB; Swartz, T; Wolman, I; Daniel, Y; Amit, A;
Indirizzi:
Lis Matern Hosp, Tel Aviv Sourasky Med Ctr, Sara Racine IVF Unit, IL-64239Tel Aviv, Israel Lis Matern Hosp Tel Aviv Israel IL-64239 Unit, IL-64239Tel Aviv, Israel Tel Aviv Univ, Chaim Sheba Med Ctr, Dept Clin Epidemiol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 demiol, IL-69978 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 5, volume: 42, anno: 1999,
pagine: 292 - 296
SICI:
1046-7408(199911)42:5<292:TPROAA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREMATURE OVARIAN FAILURE; INVITRO FERTILIZATION; AUTOIMMUNITY; PREGNANCY;
Keywords:
autoantibodies; autoimmunity; ovarian antibodies; reproductive failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Amit, A Lis Matern Hosp, Tel Aviv Sourasky Med Ctr, Sara Racine IVF Unit, 6 Weizman St, IL-64239 Tel Aviv, Israel Lis Matern Hosp 6 Weizman St Tel Aviv Israel IL-64239 viv, Israel
Citazione:
E. Geva et al., "The possible role of antiovary antibodies in repeated in vitro fertilization failures", AM J REPROD, 42(5), 1999, pp. 292-296

Abstract

PROBLEM: The study was conducted to investigate the possible role of circulating ovarian autoantibodies (ov-ab) in patients with repeated in vitro fertilization-embryo transfer (IVF-ET) failure and to evaluate the effectiveness of immunosuppression treatment in these patients. METHOD OF STUDY: The study group comprised 80 IVF patients who had five ormore failed treatment cycles (mean 10.2; range 7-22). The presence of ov-ab was compared between these women and 1) 50 IVF patients who conceived during the first three treatment cycles; 2) 50 healthy nulligravidae. All participants were seronegative to nonorgan-specific and antithyroid autoantibodies. Patients in the study group who were positive for ov-ab were treated with 10 mg/day prednisone starting 1 month before ovulation induction. Embryo grading was compared in the IVF cycles before and after treatment. RESULTS: Ov-ab were found in ten patients (12.5%) in the study group, compared to none in the control groups (P = 0.01). Nine of the patients positive for ov-ab were treated with prednisone for their following cycle. A statistically significant improvement in embryo grading was noted. Three patients conceived after treatment (33%), with a take-home baby rate of 22%, compared to only six patients (8.6%) who conceived among the rest of the seronegative study group, with a take-home baby rate of 7.1% (P = 0.05). CONCLUSIONS: Ov-ab are a possible marker of an autoimmune disorder that may be one of the causes of repeated IVF failures. Immunosuppression treatment may prove efficient in ov-ab seropositive patients with repeated IVF failures by improving embryo grading and pregnancy rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:05:14