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Titolo:
Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder
Autore:
Bremner, JD; Narayan, M; Staib, LH; Southwick, SM; McGlashan, T; Charney, DS;
Indirizzi:
VA Connecticut Healthcare Syst, Yale VA PET Ctr 115A, W Haven, CT 06516 USA VA Connecticut Healthcare Syst W Haven CT USA 06516 W Haven, CT 06516 USA Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Diagnost Radiol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 , Dept Psychiat, New Haven, CT 06510 USA Yale Psychiat Inst, W Haven, CT USA Yale Psychiat Inst W Haven CT USAYale Psychiat Inst, W Haven, CT USA Natl Ctr Posttraumat Stress Disorder, W Haven, CT USA Natl Ctr PosttraumatStress Disorder W Haven CT USA der, W Haven, CT USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 11, volume: 156, anno: 1999,
pagine: 1787 - 1795
SICI:
0002-953X(199911)156:11<1787:NCOMOC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; MEDIAL PREFRONTAL CORTEX; FUNCTIONAL NEUROANATOMY; HIPPOCAMPAL VOLUME; PSYCHOPHYSIOLOGICAL ASSESSMENT; DIFFERENTIAL CONTRIBUTION; SYMPTOM PROVOCATION; CINGULATE CORTEX; COMBAT VETERANS; IMAGERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Bremner, JD VA Connecticut Healthcare Syst, Yale VA PET Ctr 115A, 950 Campbell Ave, W Haven, CT 06516 USA VA Connecticut Healthcare Syst 950 CampbellAve W Haven CT USA 06516
Citazione:
J.D. Bremner et al., "Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder", AM J PSYCHI, 156(11), 1999, pp. 1787-1795

Abstract

Objective: Childhood sexual abuse is very common in our society, but little is known about the long-term effects of abuse on brain function. The purpose of this study was to measure neural correlates of memories of childhoodabuse in sexually abused women with and without the diagnosis of posttraumatic stress disorder (PTSD), Method: Twenty-two women with a history of childhood sexual abuse underwent injection Of [O-15]H2O, followed by positron emission tomography imaging of the brain while they listened to neutral andtraumatic (personalized childhood sexual abuse events) scripts. Brain blood flow during exposure to traumatic and neutral scripts was compared for sexually abused women with and without PTSD, Results: Memories of childhood sexual abuse were associated with greater increases in blood flow in portions of anterior prefrontal cortex (superior and middle frontal gyri-areas 6 and 9), posterior cingulate (area 31), and motor cortex in sexually abused women with PTSD than in sexually abused women without PTSD. Abuse memories were associated with alterations in blood flow in medial prefrontal cortex, with decreased blood flow in subcallosal gyrus (area 25), and a failure of activation in anterior cingulate (area 32), There was also decreased blood flow in right hippocampus, fusiform/inferior temporal gyrus, supramarginal gyrus, and visual association cortex in women with PTSD relative to women without PTSD. Conclusions: These findings implicate dysfunction of medial prefrontal cortex (subcallosal gyrus and anterior cingulate), hippocampus, and visual association cortex in pathological memories of childhood abuse in women with PTSD. Increased activation in posterior cingulate and motor cortex was seen in women with PTSD. Dysfunction in these brain areas may underlie PTSD symptoms provoked by traumatic reminders in subjects with PTSD.

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Documento generato il 25/01/20 alle ore 16:27:36