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Titolo:
Neuroanatomic and functional correlates of depressed mood - The Cardiovascular Health Study
Autore:
Sato, R; Bryan, RN; Fried, LP;
Indirizzi:
Johns Hopkins Med Inst, Dept Med, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 es, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD USAJohns Hopkins Univ Baltimore MD USA h, Dept Epidemiol, Baltimore, MD USA Johns Hopkins Med Inst, Div Neuroradiol, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 9, volume: 150, anno: 1999,
pagine: 919 - 929
SICI:
0002-9262(19991101)150:9<919:NAFCOD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINI-MENTAL STATE; POSTSTROKE DEPRESSION; BASAL GANGLIA; DISEASE; STROKE; BRAIN; MR; PREVALENCE; DISORDERS; LESIONS;
Keywords:
aged; cerebral infarction; cerebrovascular disorders; depression; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Fried, LP Johns Hopkins Med Inst, Dept Med, Welch Ctr Prevent Epidemiol & Clin Res, 2024 E Monument St,Suite 2-600, Baltimore, MD 21205 USA Johns Hopkins Med Inst 2024 E Monument St,Suite 2-600 Baltimore MD USA 21205
Citazione:
R. Sato et al., "Neuroanatomic and functional correlates of depressed mood - The Cardiovascular Health Study", AM J EPIDEM, 150(9), 1999, pp. 919-929

Abstract

Although a number of studies suggest an association between stroke and depression, few have examined the relation between magnetic resonance imaging (MRI)-identified lesions and depression among community-dwelling older adults. This cross-sectional study sought to assess the association between MRIinfarcts in the basal ganglia and non-basal-ganglia areas, potential functional consequences of these lesions, and depressive symptomatology in 3,371US men and women aged 65 years or older who participated in the Cardiovascular Health Study between 1992 and 1994. By using multiple linear regression models, the authors found that after adjustment for age, gender, and stroke history, Center for Epidemiologic Studies Depression Scale scores were independently associated with non-basal-ganglia lesions (p = 0.04) but were not independently associated with basal ganglia lesions (p = 0.11). When measures of physical disability and cognitive impairment were added to the models, these measures displaced MRI-identified infarcts in their associationwith depressive symptoms. in additional models, hemispheric location and size of the basal ganglia lesion were found to have no relation to depression levels. These results suggest that the functional consequences of cerebrovascular disease may be the causal pathway by which basal ganglia and non-basal-ganglia lesions are associated with depressive symptomatology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 14:45:53