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Titolo:
Possible role of proinflammatory cytokines in heart allograft coronary artery disease
Autore:
Gullestad, L; Simonsen, S; Ueland, T; Holm, T; Aass, H; Andreassen, AK; Madsen, S; Geiran, O; Froland, SS; Aukrust, P;
Indirizzi:
Univ Hosp, Rikshosp, Dept Cardiol, Div Heart & Lung Dis, Oslo, Norway UnivHosp Oslo Norway Dept Cardiol, Div Heart & Lung Dis, Oslo, Norway Univ Hosp, Rikshosp, Dept Cardiothorac Surg, Div Heart & Lung Dis, Oslo, Norway Univ Hosp Oslo Norway iothorac Surg, Div Heart & Lung Dis, Oslo, Norway Univ Hosp, Rikshosp, Infect Dis Sect, Oslo, Norway Univ Hosp Oslo Norway niv Hosp, Rikshosp, Infect Dis Sect, Oslo, Norway Univ Hosp, Rikshosp, Internal Med Res Inst, Dept Med, Oslo, Norway Univ Hosp Oslo Norway sp, Internal Med Res Inst, Dept Med, Oslo, Norway Univ Oslo Hosp, Rikshosp, Sect Clin Immunol & Infect Dis, Dept Med A, N-0027 Oslo, Norway Univ Oslo Hosp Oslo Norway N-0027 t Dis, Dept Med A, N-0027 Oslo, Norway
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 9, volume: 84, anno: 1999,
pagine: 999 - 1003
SICI:
0002-9149(19991101)84:9<999:PROPCI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAFT VASCULAR-DISEASE; NECROSIS-FACTOR-ALPHA; CARDIAC ALLOGRAFTS; ENDOTHELIAL-CELLS; TRANSPLANTATION; REJECTION; ARTERIOSCLEROSIS; EXPRESSION; VASCULOPATHY; ARTERIOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Aukrust, P Univ Oslo Hosp, Rikshosp, Sect Clin Immunol & Infect Dis, Dept Med A, N-0027 Oslo, Norway Univ Oslo Hosp Oslo Norway N-0027 Med A, N-0027 Oslo, Norway
Citazione:
L. Gullestad et al., "Possible role of proinflammatory cytokines in heart allograft coronary artery disease", AM J CARD, 84(9), 1999, pp. 999-1003

Abstract

Transplant coronary artery disease (Tx-CAD) is the main determinant of long-term prognosis after heart trans, plantation. Immunologic processes may play a central role in the development of Tx-CAD, but the pathogenesis has not been fully clarified. We examined plasma levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukins (IL)-1 beta and IL-6, and the CC-chemokine macrophage chemoattractant protein-1 (MCP-1)in 62 cardiac allograft recipients undergoing yearly heart catherization with coronary angiography for evaluation of graft disease. In this cross-sectional study, we found significantly increased levels of Il-1 beta, IL-6, TNF-alpha, and MCP-1 compared with healthy controls even several years (median 7 years) after transplantation in periods with no intercurrent illness. Although no significant differences were found in plasma bevels of IL-1 beta and TNF-alpha between patients with (n = 25) and without (n = 37) Tx-CAD,the Tx-CAD group had significantly increased levels of IL-6 and MCP-1 compared with both controls and transplant recipients without Tx-CAD. IncreasedIL-6 levels compared with controls were found only in patients with Tx-CAD. Finally, while there was no significant relation between Tx-CAP and altered lipid status, the combination of high plasma concentrations of IL-6 or MCP-1 and high low-density lipoprotein cholesterol was strongly associated with increased occurrence of Tx-CAD. These findings indicate that cardiac allograft recipients have a persistent immune activation long term after transplantation. This activation, as particularly reflected in increased MCP-1 and IL-6 levels, may be related to the development of Tx-CAD. (C) 1999 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:49:50