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Titolo:
ARCTIC: Assessment of haemodynamic response in patients with congestive heart failure to telmisartan: A multicentre dose-ranging study in Canada
Autore:
Parker, AB; Azevedo, ER; Baird, MG; Smith, SJ; Arnold, JMO; Humen, DP; Moe, GW; Parker, JO; Butt, RW; Parker, JD;
Indirizzi:
Univ Ottawa, Inst Heart, Ottawa, ON, Canada Univ Ottawa Ottawa ON CanadaUniv Ottawa, Inst Heart, Ottawa, ON, Canada Univ Western Ontario, Ottawa, ON, Canada Univ Western Ontario Ottawa ON Canada estern Ontario, Ottawa, ON, Canada Univ Alberta Hosp, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp Edmonton AB Canada T6G 2B7 Edmonton, AB T6G 2B7, Canada Queens Univ, Kingston Gen Hosp, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 Hosp, Kingston, ON K7L 3N6, Canada Boehringer Ingelheim Canada Ltd, Burlington, ON, Canada Boehringer Ingelheim Canada Ltd Burlington ON Canada lington, ON, Canada Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Hosp, Toronto, ON M5G 1X5, Canada St Michaels Hosp, Socar Cardiac Res, Toronto, ON M5B 1W8, Canada St Michaels Hosp Toronto ON Canada M5B 1W8 s, Toronto, ON M5B 1W8, Canada Univ Toronto, Toronto, ON, Canada Univ Toronto Toronto ON CanadaUniv Toronto, Toronto, ON, Canada
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 5, volume: 138, anno: 1999,
parte:, 1
pagine: 843 - 848
SICI:
0002-8703(199911)138:5<843:AAOHRI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOSARTAN; ANTAGONISTS; INHIBITORS; RECEPTORS; ENALAPRIL; COUGH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Parker, JD Univ Toronto, Mt Sinai Hosp, Dept Med, Div Cardiol, 600 Univ Ave,Room 1609, Toronto, ON M5G 1X5, Canada Univ Toronto 600 Univ Ave,Room 1609 Toronto ON Canada M5G 1X5 a
Citazione:
A.B. Parker et al., "ARCTIC: Assessment of haemodynamic response in patients with congestive heart failure to telmisartan: A multicentre dose-ranging study in Canada", AM HEART J, 138(5), 1999, pp. 843-848

Abstract

Background The aim of this study was to examine the acute hemodynamic and neurohormonal effects of the angiotensin II antagonist telmisartan relativeto placebo in patients with chronic symptomatic (New York Heart Association class II to III) congestive heart failure and to explore the dose-response relation for these effects. Methods and Results After baseline hemodynamic and neurohormonal measurements made with the use of a pulmonary artery and radial arterial catheter, 82 patients were randomly assigned to placebo or 10, 20, 40, or 80 mg of telmisartan in a double-blind fashion. Hemodynamic and neurohormonal measurements were carried out over 24 hours. Telmisartan caused significant decreases in systemic arterial, pulmonary arterial, and pulmonary capillary wedge pressures with evidence of a dose-response relation for each of these parameters. The drug had no significant effects on heart rate, cardiac index, or systemic vascular resistance. Telmisartan did not have consistent effects on either plasma norepinephrine or plasma atrial natriuretic peptide levels,although it did cause significant increases in both plasma renin activity and angiotensin II levels at higher doses. Conclusions The acute administration of the angiotensin II antagonist telmisartan was associated with significant dose-dependent reductions in systemic arterial blood pressure and pulmonary pressures. Long-term follow-up studies are required to translate changes in hemodynamic parameters into a clinical benefit.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:13:52