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Titolo:
Embryo vaccination of turkeys against Newcastle disease infection with recombinant fowlpox virus constructs containing interferons as adjuvants
Autore:
Rautenschlein, S; Sharma, JM; Winslow, BJ; McMillen, J; Junker, D; Cochran, M;
Indirizzi:
Univ Minnesota, Coll Vet Med, Dept Vet Pathobiol, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Vet Pathobiol, St Paul, MN 55108 USA Syntro Res Labs, San Diego, CA 92121 USA Syntro Res Labs San Diego CA USA92121 Res Labs, San Diego, CA 92121 USA
Titolo Testata:
VACCINE
fascicolo: 5-6, volume: 18, anno: 1999,
pagine: 426 - 433
SICI:
0264-410X(19991014)18:5-6<426:EVOTAN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHICKEN INTERFERON; IMMUNE-RESPONSE; IN-VITRO; GAMMA; CYTOKINES; ALPHA; IFN; INDUCTION; CHALLENGE; VACCINES;
Keywords:
turkeys; interferons; in ovo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, JM Univ Minnesota, Coll Vet Med, Dept Vet Pathobiol, 1971 Commonwealth Ave, St Paul, MN 55108 USA Univ Minnesota 1971 Commonwealth Ave St Paul MN USA 55108 8 USA
Citazione:
S. Rautenschlein et al., "Embryo vaccination of turkeys against Newcastle disease infection with recombinant fowlpox virus constructs containing interferons as adjuvants", VACCINE, 18(5-6), 1999, pp. 426-433

Abstract

Recombinant fowlpox viruses (rFPV) expressing the fusion and hemagglutinin-neuraminidase glycoproteins of Newcastle disease virus (NDV) as well as chicken type I interferon (IFN) or type II IFN were used to vaccinate specific pathogen-free (SPF) turkeys in ovo. No significant changes in the hatchability, survival rate, performance and weight gain were observed after vaccination with the rFPV vaccines in comparison to diluent-inoculated embryos. The rFPV-NDV-IFN-II construct induced the onset of anti-NDV antibody production in SPF birds at one week post hatch, one week earlier than other vaccine constructs. Three to five weeks post hatch, the turkeys were challenged with the neurotropic velogenic NDV strain Texas GB (NDV-GBTx). The rFPV-NDV-IFN-II construct was the most protective vaccine against NDV, rFPV vaccines significantly (p < 0.05) suppressed the mitogenic response of peripheral blood leukocytes in vaccinated turkeys in comparison to placebo inoculated controls at 25 days post vaccination. Birds vaccinated with rFPV-NDV-IFN-I construct did not have an inhibition in the mitogenic response. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:04:40