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Titolo:
Both glutamate receptor antagonists and prefrontal cortex lesions prevent induction of cocaine sensitization and associated neuroadaptations
Autore:
Li, Y; Hu, XT; Berney, TG; Vartanian, AJ; Stine, CD; Wolf, ME; White, FJ;
Indirizzi:
Finch Univ Hlth Sci Chicago Med Sch, Dept Cellular & Mol Pharmacol, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064 , IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch, Dept Neurosci, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064 , IL 60064 USA
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 34, anno: 1999,
pagine: 169 - 180
SICI:
0887-4476(199912)34:3<169:BGRAAP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; MESOACCUMBENS DOPAMINE SYSTEM; INDUCED BEHAVIORAL SENSITIZATION; NITRIC-OXIDE SYNTHASE; NUCLEUS-ACCUMBENS NEURONS; IBOTENIC ACID LESIONS; LOCOMOTOR-ACTIVITY; NMDA RECEPTOR; EXTRACELLULAR DOPAMINE; TYROSINE-HYDROXYLASE;
Keywords:
dopamine; excitatory amino acids; ventral tegmental area; nucleus accumbens; dopamine D1 receptors; dopamine D2 receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: White, FJ Finch Univ Hlth Sci Chicago Med Sch, Dept Cellular & Mol Pharmacol, 3333 Green Bay Rd, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch 3333 Green Bay Rd N Chicago IL USA 60064
Citazione:
Y. Li et al., "Both glutamate receptor antagonists and prefrontal cortex lesions prevent induction of cocaine sensitization and associated neuroadaptations", SYNAPSE, 34(3), 1999, pp. 169-180

Abstract

Behavioral sensitization to psychomotor stimulants is accompanied by a number of alterations in the mesoaccumbens dopamine (DA) system, including DA autoreceptor subsensitivity in the ventral tegmental area (VTA) and DA D1 receptor supersensitivity in the nucleus accumbens (NAc). We investigated the role of excitatory amino acid (EAA) transmission in the induction of cocaine sensitization and these accompanying DA receptor alterations. To do so,we used three glutamate receptor antagonists, the noncompetitive NMDA receptor antagonist MK-801 (0.1 mg/kg), the competitive NMDA receptor antagonist CGS 19755 (10.0 mg/kg), and the AMPA receptor antagonist NBQX (12.5 mg/kg). Rats received daily double injections of either one of these antagonistsor saline with either cocaine (15.0 mg/kg) or saline for 5 days. Cocaine sensitization was defined as an increase in horizontal locomotor activity inresponse to cocaine challenge (7.5 mg/kg) on the third day of withdrawal. All three antagonists prevented the induction of cocaine sensitization. Extracellular single cell recordings revealed that these antagonists also prevented the induction of DA autoreceptor subsensitivity in the VTA and DAD1 receptor supersensitivity in the NAc. To determine whether the relevant glutamate receptors were under regulation by medial prefrontal cortex (mPFC) EAA efferents, we next lesioned the mPFC bilaterally with ibotenic acid at least 7 days before repeated cocaine treatment began. These lesions also prevented the induction of cocaine sensitization and the associated neuroadaptations. Our findings indicate that glutamate transmission from mPFC to the mesoaccumbens DA system is critical for the induction of cocaine sensitization and its cellular correlates. Synapse 34:169-180, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:42:55