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Titolo:
Effects of withdrawal from an escalating dose schedule of d-amphetamine onsexual behavior in the male rat
Autore:
Barr, AM; Fiorino, DF; Phillips, AG;
Indirizzi:
Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada Univ British Columbia Vancouver BC Canada V6T 1Z4 ver, BC V6T 1Z4, Canada Eisai & Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 3002635, Japan Eisai & Co Ltd Tsukuba Ibaraki Japan 3002635 kuba, Ibaraki 3002635, Japan
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 64, anno: 1999,
pagine: 597 - 604
SICI:
0091-3057(199911)64:3<597:EOWFAE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STIMULATION REWARD; COCAINE WITHDRAWAL; DEPRESSED MEN; ANIMAL-MODELS; FEMALE RAT; MOTIVATION; DOPAMINE; DEPENDENCE; NEUROBIOLOGY; SYSTEM;
Keywords:
amphetamine; psychostimulant; withdrawal; depression; anhedonia; sexual behavior; copulation; anticipatory; preparatory; consummatory; male rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Phillips, AG Univ British Columbia, Dept Psychol, 2136 W Mall, Vancouver, BC V6T 1Z4, Canada Univ British Columbia 2136 W Mall Vancouver BC Canada V6T 1Z4
Citazione:
A.M. Barr et al., "Effects of withdrawal from an escalating dose schedule of d-amphetamine onsexual behavior in the male rat", PHARM BIO B, 64(3), 1999, pp. 597-604

Abstract

The present study sought to determine the effect of withdrawal from an escalating dose schedule of d-amphetamine on sexual behavior in male rats. Tests were conducted every 5 days until stable levels of sexual behavior were obtained. With repeated testing, male rats displayed an increase in their exploration of the testing chambers prior to the introduction of an estrous female. Half of the male rats were then subjected to a 4-day escalating dose schedule of d-amphetamine administration (1-12 mg/kg), while half received vehicle. Twelve hours after the final drug injection, subjects were tested for sexual behavior. Withdrawal from the drug was associated with decrements in several motivational components of sexual behavior, including decreased anticipatory locomotor and increased postejaculatory intervals, while consummatory measures remained largely unaffected. This pattern of sexual deficits resembles those seen in human depressive disorders, and therefore, provides additional support for the use of psychostimulant withdrawal as a rodent model of depression. (C) 1999 Elsevier Science Inc.

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Documento generato il 25/09/20 alle ore 13:42:35