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Titolo:
Circadian time does not modify the prepulse inhibition response or its attenuation by apomorphine
Autore:
Weiss, IC; Feldon, J; Domeney, AM;
Indirizzi:
Swiss Fed Inst Technol, Behav Biol Lab, CH-8603 Schwerzenbach, SwitzerlandSwiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 64, anno: 1999,
pagine: 501 - 505
SICI:
0091-3057(199911)64:3<501:CTDNMT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; ANIMAL-MODEL; RAT STRAINS; REFLEX; DOPAMINE; CLOZAPINE; SCHIZOPHRENICS; POTENTIATION; ANTAGONISTS; HABITUATION;
Keywords:
prepulse inhibition; circadian time; apomorphine; Wistar rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Feldon, J Swiss Fed Inst Technol, Behav Biol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland Swiss Fed Inst Technol Schorenstr 16 Schwerzenbach Switzerland CH-8603
Citazione:
I.C. Weiss et al., "Circadian time does not modify the prepulse inhibition response or its attenuation by apomorphine", PHARM BIO B, 64(3), 1999, pp. 501-505

Abstract

The present study investigated the influence of circadian time (experimental testing during the light or dark phase of the light:dark cycle) on the acoustic startle response (ASR), prepulse inhibition (PPI), and apomorphine-induced PPI deficits in Wistar rats housed under a reversed light:dark cycle (lights off at 0700 h and on at 1900 h). There was no significant difference in the startle response amplitude or PPI response of animals tested during the light phase compared with those tested during the dark phase. Similarly, the response to apomorphine (0.01-0.05 mg/kg subcutaneously) was not modulated by circadian time. Thus, under the conditions adopted in the present study, ASR, PPI, and apomorphine-induced PPI deficits remained stable across the circadian cycle. Such findings may be of importance for other investigators using the PPI paradigm to study brain plasticity mechanisms and pharmacological manipulations of apomorphine-induced PPI deficits in rats housed under normal or reversed light:dark cycle conditions. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:04:52