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Titolo:
The energetics of T4 lysozyme reveal a hierarchy of conformations
Autore:
Llinas, M; Gillespie, B; Dahlquist, FW; Marqusee, S;
Indirizzi:
Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 egon, Inst Mol Biol, Eugene, OR 97403 USA Univ Oregon, Dept Chem, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 v Oregon, Dept Chem, Eugene, OR 97403 USA Univ Oregon, Dept Phys, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 v Oregon, Dept Phys, Eugene, OR 97403 USA
Titolo Testata:
NATURE STRUCTURAL BIOLOGY
fascicolo: 11, volume: 6, anno: 1999,
pagine: 1072 - 1078
SICI:
1072-8368(199911)6:11<1072:TEOTLR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROGEN-EXCHANGE; BACTERIOPHAGE-T4 LYSOZYME; PROTEIN-STRUCTURE; MOLECULAR-DYNAMICS; DOMAIN MOTIONS; SIDE-CHAINS; STABILITY; EQUILIBRIUM; MUTANT; NMR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Marqusee, S Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA Univ Calif Berkeley 229 Stanley Hall Berkeley CA USA 94720 USA
Citazione:
M. Llinas et al., "The energetics of T4 lysozyme reveal a hierarchy of conformations", NAT ST BIOL, 6(11), 1999, pp. 1072-1078

Abstract

We have used native state exchange to examine the energy landscape of the well-characterized protein T4 lysozyme. Although the protein exhibits two-state behavior by traditional probes, the energy landscape determined here is much more complex. The average stability of the C-terminal subdomain is significantly higher than that for the N-terminus suggesting at least two regions of unfolding. At a more detailed level, there appears to be a broad continuum of stabilities throughout each region. The overall subdomain hierarchy of energies does not mirror data on the folding pathway for this protein, challenging the relationship between energy landscapes and folding trajectories.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:35:53