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Titolo:
Regulation of Wnt signaling by sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin
Autore:
Zorn, AM; Barish, GD; Williams, BO; Lavender, P; Klymkowsky, MW; Varmus, HE;
Indirizzi:
Wellcome Trust, Canc Res Campaign, Inst Canc & Dev Biol, Cambridge CB2 1QR, England Wellcome Trust Cambridge England CB2 1QR iol, Cambridge CB2 1QR, England Univ London Kings Coll, Dept Resp Med & Allergy, London SE1 9RT, England Univ London Kings Coll London England SE1 9RT y, London SE1 9RT, England NCI, Div Basic Sci, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Div Basic Sci, NIH, Bethesda, MD 20892 USA Univ Colorado, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309Univ Colorado, Boulder, CO 80309 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 4, volume: 4, anno: 1999,
pagine: 487 - 498
SICI:
1097-2765(199910)4:4<487:ROWSBS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOGEN-SYNTHASE KINASE-3; TRANSCRIPTION FACTOR LEF-1; XENOPUS EMBRYOS; AXIS SPECIFICATION; SPEMANN ORGANIZER; BINDING-SITES; DNA-BINDING; GENE; DROSOPHILA; DOMAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Zorn, AM Wellcome Trust, Canc Res Campaign, Inst Canc & Dev Biol, Tennis Court Rd, Cambridge CB2 1QR, England Wellcome Trust Tennis Court Rd Cambridge England CB2 1QR England
Citazione:
A.M. Zorn et al., "Regulation of Wnt signaling by sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin", MOL CELL, 4(4), 1999, pp. 487-498

Abstract

Using a functional screen in Xenopus embryos, we identified a novel function for the HMG box protein XSox17 beta. Ectopic expression of XSox17 beta ventralizes embryos by inhibiting the Wnt pathway downstream of beta-cateninbut upstream of the Wnt-responsive gene Siamois. XSox17 beta also represses transactivation of a TCF/LEF-dependent reporter construct by Wnt and beta-catenin. In animal cap experiments, it both activates transcription of endodermal genes and represses beta-catenin-stimulated expression of dorsal genes. The inhibition activity of XSox17 beta maps to a region C-terminal to the HMG box; this region of XSox17 beta physically interacts with the Armadillo repeats of beta-catenin. Two additional Sox proteins, XSox17 alpha andXSox3, likewise bind to beta-catenin and inhibit its TCF-mediated signaling activity. These results reveal an unexpected mechanism by which Sox proteins can modulate Wnt signaling pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:13:30