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Titolo:
A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila
Autore:
Sevrioukov, EA; He, JP; Moghrabi, N; Sunio, A; Kramer, H;
Indirizzi:
Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 , Ctr Basic Neurosci, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Ctr, Dept Cell Biol, Dallas, TX 75235 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 4, volume: 4, anno: 1999,
pagine: 479 - 486
SICI:
1097-2765(199910)4:4<479:ARFTDO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEC1 HOMOLOG; MULTIVESICULAR ENDOSOMES; NEUROTRANSMITTER RELEASE; SYNAPTIC TRANSMISSION; TRANSPORT VESICLES; PROTEIN COMPLEX; YEAST VACUOLE; R7 INDUCTION; BIOGENESIS; MUTATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Kramer, H Univ Texas, SW Med Ctr, Ctr Basic Neurosci, 5323 Harry Hines Blvd, Dallas,TX 75235 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75235X 75235 USA
Citazione:
E.A. Sevrioukov et al., "A role for the deep orange and carnation eye color genes in lysosomal delivery in Drosophila", MOL CELL, 4(4), 1999, pp. 479-486

Abstract

deep orange and carnation are two of the classic eye color genes in Drosophila, Here, we demonstrate that Deep orange is part of a protein complex that localizes to endosomal compartments. A second component of this complex is Carnation, a homolog of Sec1p-like regulators of membrane fusion. Because complete loss of deep orange function is lethal, the role of this complexin intracellular trafficking was analyzed in deep orange mutant clones. Retinal cells devoid of deep orange function completely lacked pigmentation and exhibited exaggerated multivesicular structures, Furthermore, a defect in endocytic trafficking was visualized in developing photoreceptor cells. These results provide direct evidence that eye color mutations of the granule group also disrupt vesicular trafficking to lysosomes.

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Documento generato il 04/07/20 alle ore 05:12:52