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Titolo:
From neural stem cells to myelinating oligodendrocytes
Autore:
Rogister, B; Ben-Hur, T; Dubois-Dalcq, M;
Indirizzi:
Univ Liege, Dept Human Physiol, Liege, Belgium Univ Liege Liege BelgiumUniv Liege, Dept Human Physiol, Liege, Belgium Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Neurol, IL-91010 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91010 -91010 Jerusalem, Israel Inst Pasteur, Unite Neurovirol & Regenerat Syst Nerveux, Paris, France Inst Pasteur Paris France virol & Regenerat Syst Nerveux, Paris, France
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 4-5, volume: 14, anno: 1999,
pagine: 287 - 300
SICI:
1044-7431(199910/11)14:4-5<287:FNSCTM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ZONE PROGENITOR CELLS; DEVELOPING RAT-BRAIN; GROWTH-FACTOR; SUBVENTRICULAR ZONE; THYROID-HORMONE; PRECURSOR CELLS; CEREBRAL-CORTEX; ZINC-FINGER; OPTIC-NERVE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Rogister, B Univ Liege, Dept Human Physiol, Liege, Belgium Univ Liege Liege Belgium Dept Human Physiol, Liege, Belgium
Citazione:
B. Rogister et al., "From neural stem cells to myelinating oligodendrocytes", MOL CELL NE, 14(4-5), 1999, pp. 287-300

Abstract

The potential to generate oligodendrocytes progenitors (OP) from neural stem cells (NSCs) exists throughout the developing CNS. Yet, in the embryonicspinal cord, the oligodendrocyte phenotype is induced by sonic hedgehog ina restricted anterior region. In addition, neuregulins are emerging as potent regulators of early and late OP development. The ability to isolate andgrow NSCs as well as glial-restricted progenitors has revealed that FGF2 and thyroid hormone favor an oligodendrocyte fate. Analysis of genetically modified mice showed that PDGF controls the migration and production of oligodendrocytes in vivo. Interplay between mitogens, thyroid hormone, and neurotransmitters may maintain the undifferentiated stage or result in OP growth arrest. Notch signaling by axons inhibits oligodendrocyte differentiationuntil neuronal signals-linked to electrical activity-trigger initiation ofmyelination. To repair myelin in adult CNS, multipotential neural precursors, rather than slowly cycling OF, appear the cells of choice to rapidly generate myelin-forming cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:40:33