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Titolo:
Epstein-Barr virus DNA in the cerebrospinal fluid of patients with human immunodeficiency virus infection and central nervous system disorders
Autore:
Portolani, M; Cermelli, C; Meacci, M; Pietrosemoli, P; Sabbatini, AMT; Cerri, MC; Guaraldi, G; De Rienzo, B;
Indirizzi:
Univ Modena, Dept Hyg Microbiol & Biostat, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 robiol & Biostat, I-41100 Modena, Italy
Titolo Testata:
MICROBIOLOGICA
fascicolo: 4, volume: 22, anno: 1999,
pagine: 369 - 374
SICI:
1121-7138(199910)22:4<369:EVDITC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; CYTOMEGALOVIRUS DNA; BRAIN DISORDERS; ENCEPHALITIS; BLOOD;
Keywords:
HIV infection; neurological disorders; EBV; HSV-1; PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Portolani, M Univ Modena, Dept Hyg Microbiol & Biostat, Via Campi 287, I-41100 Modena, Italy Univ Modena Via Campi 287 Modena Italy I-41100 Modena, Italy
Citazione:
M. Portolani et al., "Epstein-Barr virus DNA in the cerebrospinal fluid of patients with human immunodeficiency virus infection and central nervous system disorders", MICROBIOLO, 22(4), 1999, pp. 369-374

Abstract

Routine search for herpesvirus types 1-5 by nested polymerase chain reaction revealed Epstein-Barr virus (EBV) DNA in the cerebrospinal fluid (CSF) of ten out of seventy-nine patients with human immunodeficiency virus (HIV) infection and central nervous system (CNS) disorders not associated with the presence of primary CNS lymphomas. One out of the ten CSF samples was positive for EBV DNA only, six were also positive for microbial agents of recognised neurological pathogenicity while the remaining three samples had a high content of HIV p24 Ag. When six available CSF samples out of the ten EBV DNA positive specimens were investigated for an intrathecal EBV antibody response, all six samples proved EBV antibody-free. The concurrent detection of neurotropic infectious agents and the absence of EBV antibodies in theCSF contribute to the uncertainty on the role of EBV in the neurological illness of the patients studied. One hypothesis considered is that the presence of EBV DNA in the CSF of a large fraction of the ten patients under study is an incidental event associated with EBV reactivation in the host's peripheral blood monocytes, but not related to the genesis of neurological disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 10:10:54