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Titolo:
Phenotypic patterns of HIV-1 clonal populations during highly active antiretroviral therapy (HAART)
Autore:
Favia, A; Di Stefano, M; Fiore, JR; Pastore, G; Angarano, G;
Indirizzi:
Univ Bari, Clin Infect Dis, Bari, Italy Univ Bari Bari ItalyUniv Bari, Clin Infect Dis, Bari, Italy
Titolo Testata:
MICROBIOLOGICA
fascicolo: 4, volume: 22, anno: 1999,
pagine: 301 - 307
SICI:
1121-7138(199910)22:4<301:PPOHCP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR-CELLS; BIOLOGICAL PHENOTYPE; VIRUS POPULATIONS; ZIDOVUDINE RESISTANCE; VIRAL PHENOTYPE; INFECTION; INDIVIDUALS; LOAD; PHOSPHORYLATION; PROGRESSION;
Keywords:
HIV-1; biological clones; viral phenotype; HAART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Favia, A Univ Bari, Clin Infect Dis, Bari, Italy Univ Bari Bari ItalyUniv Bari, Clin Infect Dis, Bari, Italy
Citazione:
A. Favia et al., "Phenotypic patterns of HIV-1 clonal populations during highly active antiretroviral therapy (HAART)", MICROBIOLO, 22(4), 1999, pp. 301-307

Abstract

Several studies have demonstrated that during HIV-1 infection many different viral clones may co-exist in the same individual. These clones may differ regarding their biological phenotype and may influence both the natural history of infection and the clinical response to antiretroviral therapy. The aim of the present study was to investigate the influences of combination therapies including protease inhibitors (HAART) on the phenotypical pattern of HIV-1 biological clones in peripheral blood mononuclear cells. Viral isolation and biological characterisation of bulk isolates and clonal viral isolates were performed on two AIDS patients, before and after three months of antiretroviral therapy. A decrease of viral load in plasma specimens in association with a change of clonal composition during antiretroviral therapy was observed in both patients during treatment. Before therapy both of the patients had a syncytium inducing (SI) bulk isolate and the majority of the biological clones werecharacterised as SI. After treatment, the bulk isolates were still SI in both cases, but the majority of biological clones were characterised as non-syncytium inducing (NSI). These results suggest that HIV clonal composition and relative phenotypic pattern undergo different changes not only during the natural course of HIVinfection but also while patients are on antiretroviral combination therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:15:44