Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Resistance of the aged myocardium to exercise-induced chronic changes in glucose transport related protein content
Autore:
Martineau, LC; Chadan, SG; Parkhouse, WS;
Indirizzi:
Simon Fraser Univ, Sch Kinesiol, Metab Biochem Lab, Burnaby, BC V5A 1S6, Canada Simon Fraser Univ Burnaby BC Canada V5A 1S6 , Burnaby, BC V5A 1S6, Canada
Titolo Testata:
MECHANISMS OF AGEING AND DEVELOPMENT
fascicolo: 1-2, volume: 110, anno: 1999,
pagine: 109 - 118
SICI:
0047-6374(19991001)110:1-2<109:ROTAMT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOBARIC HYPOXIA; PHYSICAL-ACTIVITY; SKELETAL-MUSCLE; YOUNG-ADULT; RATS; HEART; INSULIN; GLUT-4; TRANSLOCATION; CONTRACTIONS;
Keywords:
heart; glut-1; glut-4; glucose transporters; exercise;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Parkhouse, WS Simon Fraser Univ, Sch Kinesiol, Metab Biochem Lab, Burnaby,BC V5A 1S6, Canada Simon Fraser Univ Burnaby BC Canada V5A 1S6 V5A 1S6, Canada
Citazione:
L.C. Martineau et al., "Resistance of the aged myocardium to exercise-induced chronic changes in glucose transport related protein content", MECH AGE D, 110(1-2), 1999, pp. 109-118

Abstract

The effects of acute exercise on myocardial content of glut-1 and glut-4 transporters, insulin and IGF-1 receptors were assessed in control and chronically exercised 24-month-old C57Bl/6 mice. Myocardial glut-1, glut-4, insulin receptor (Ins R) and insulin like growth factor-1 receptor (IGF-1 R) protein levels were unaffected by 36 weeks of chronic exercise. However, myocardial protein content of glut-1, but not glut-4, was increased 12 h following an acute exercise bout in control (46%) and chronically exercised (83%)aged animals. This increased glut-1 response following acute exercise occurred despite the finding that the chronic exercise failed to increase cardiac or skeletal muscle oxidative capacity as indicated by no change in citrate synthase activity. Myocardial IGF-1 R content was unaffected by acute exercise whereas Ins R protein content was decreased 12 h following the acuteexercise bout in the chronically exercised (-52%) and control (-28%) animals. The effect of acute exercise on the protein content of glut-1 and Ins Rwas 80 and 84% greater respectively, in the chronically exercised animals. This suggests that the amplitude of the expression of these two proteins may be increased by chronic exercise, thus constituting a form of adaptation. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:16:52