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Titolo:
Successful treatment of immunoblastic lymphadenopathy-like T-cell lymphomawith cyclosporin A
Autore:
Takemori, N; Kodaira, J; Toyoshima, N; Sato, T; Sakurai, H; Akakura, N; Kimura, S; Katagiri, M;
Indirizzi:
Asahikawa Kosei Gen Hosp, Dept Internal Med, Asahikawa, Hokkaido 0788211, Japan Asahikawa Kosei Gen Hosp Asahikawa Hokkaido Japan 0788211 0788211, Japan
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 3-4, volume: 35, anno: 1999,
pagine: 389 - 395
SICI:
1042-8194(199910)35:3-4<389:STOILT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOKINE GENE-EXPRESSION; ANGIOIMMUNOBLASTIC LYMPHADENOPATHY; SIGNAL TRANSDUCTION; HODGKINS-DISEASE; GAMMA-INTERFERON; FK506; HISTOPATHOGENESIS; DYSPROTEINEMIA; RAPAMYCIN; RELEASE;
Keywords:
IBL-like T-cell lymphoma; treatment; cyclosporin A; remission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Takemori, N Asahikawa Kosei Gen Hosp, Dept Internal Med, Asahikawa, Hokkaido 0788211, Japan Asahikawa Kosei Gen Hosp Asahikawa Hokkaido Japan 0788211 pan
Citazione:
N. Takemori et al., "Successful treatment of immunoblastic lymphadenopathy-like T-cell lymphomawith cyclosporin A", LEUK LYMPH, 35(3-4), 1999, pp. 389-395

Abstract

Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma is considered to belong to peripheral T-cell lymphoma. Its prognosis is grave and effective treatments have not been established, Recently, we gave oral cyclosporin A (CsA) to a patient with IBL-like T-cell lymphoma, and succeeded in achieving dramatic remission. In this case, serum levels of interleukin-12 (IL-12) and tumor necrosis factor-alpha (TNF alpha) were elevated and decreased or returned to normal after achieving remission. Since CsA is a potent suppressor of the immune system and most notably T-cells, the immunosuppression ofT-cell function might have played an important role in achieving remissionin this case, although the precise mechanism still remains to be elucidated. The present case indicates that administration of CsA may be a very effective and safe selection of therapy for IBL-like T-cell lymphoma, as well as analogous disorders such as IBL and angioimmunoblastic lymphadenopathy with dysproteinemia (AILD), thereby will contribute to improving the prognosis of patients with these diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:33:38