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Titolo:
Increased serum strontium levels in dialysis patients: An epidemiological survey
Autore:
Schrooten, I; Elseviers, MM; Lamberts, LV; de Broe, ME; DHaese, PC;
Indirizzi:
Univ Antwerp Hosp, Dept Nephrol Hypertens, B-2650 Edegem, Belgium Univ Antwerp Hosp Edegem Belgium B-2650 ypertens, B-2650 Edegem, Belgium
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 5, volume: 56, anno: 1999,
pagine: 1886 - 1892
SICI:
0085-2538(199911)56:5<1886:ISSLID>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATOMIC-ABSORPTION SPECTROMETRY; HEMODIALYZED PATIENTS; CALCIUM ABSORPTION; BONE-DISEASE; RATS; INHIBITION; ALUMINUM; TISSUES; RICKETS; BLOOD;
Keywords:
osteomalacia; aluminum; dialysate; renal osteodystrophy; chronic renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Schrooten, I Univ Antwerp Hosp, Dept Nephrol Hypertens, Wilrijkstr 10, B-2650 Edegem, Belgium Univ Antwerp Hosp Wilrijkstr 10 Edegem Belgium B-2650 elgium
Citazione:
I. Schrooten et al., "Increased serum strontium levels in dialysis patients: An epidemiological survey", KIDNEY INT, 56(5), 1999, pp. 1886-1892

Abstract

Background. We previously reported on increased bone strontium levels in dialysis patients with osteomalacia versus those presenting other types of renal osteodystrophy. A causal role of strontium in the development of osteomalacia was established in a chronic renal failure rat model. Methods. To further elucidate the latter issue and to find out whether dialysis patients from particular centers/countries are at an increased risk for strontium accumulation, a worldwide multicenter study was established Intotal, 834 patients from 34 dialysis centers in 23 countries were included. In each of the patients, a serum sample was taken for strontium determination, and water and dialysate samples were taken at the various steps of the water purification process. For each patient clinical data and for each center dialysis modalities were recorded. Results. Strontium levels in serum of dialysis patients showed major differences between the various centers, ranging from mean values of 25 +/- 8 mug/liter in the center with the lowest Level up to 466 +/- 90 mu g/liter inthe center with the highest concentration. It is of interest that these high levels were mainly found in developing countries. Furthermore, our data point toward a role of the final dialysate in the accumulation of the element, as indicated by the strong correlation (r = 0.74, P < 0.001) between mean serum and dialysate strontium levels. As the high tap water concentration of strontium was adequately reduced during the water purification process, contamination of the final dialysis fluid occurred by the addition of concentrates contaminated with strontium. Besides the dialysate, other factors, such as duration of dialysis, vitamin D supplements, or types of phosphate binders, played a less important role in the accumulation of the element. Conclusions. Data of this multicenter study indicate patients of particular dialysis centers to be at an increased risk for strontium accumulation. the clinical consequence of which is under current investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:09:17