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Titolo:
Bone marrow transplantation attenuates murine IgA nephropathy: Role of a stem cell disorder
Autore:
Imasawa, T; Nagasawa, R; Utsunomiya, Y; Kawamura, T; Zhong, Y; Makita, N; Muso, E; Miyawaki, S; Maruyama, N; Hosoya, T; Sakai, O; Ohno, T;
Indirizzi:
Jikei Univ, Sch Med, Dept Microbiol, Minato Ku, Tokyo 1058461, Japan JikeiUniv Tokyo Japan 1058461 icrobiol, Minato Ku, Tokyo 1058461, Japan Jikei Univ, Sch Med, Dept Internal Med, Minato Ku, Tokyo 1058461, Japan Jikei Univ Tokyo Japan 1058461 rnal Med, Minato Ku, Tokyo 1058461, Japan Saitama Med Sch, Ctr Med, Div Hemodialysis, Moroyama, Saitama, Japan Saitama Med Sch Moroyama Saitama Japan ialysis, Moroyama, Saitama, Japan Kyoto Univ, Dept Internal Med, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 oto Univ, Dept Internal Med, Kyoto 606, Japan Nippon Shinyaku Co Ltd, Res Labs, Kyoto 601, Japan Nippon Shinyaku Co LtdKyoto Japan 601 o Ltd, Res Labs, Kyoto 601, Japan Tokyo Metropolitan Inst Gerontol, Dept Mol Pathol, Tokyo, Japan Tokyo Metropolitan Inst Gerontol Tokyo Japan t Mol Pathol, Tokyo, Japan
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 5, volume: 56, anno: 1999,
pagine: 1809 - 1817
SICI:
0085-2538(199911)56:5<1809:BMTAMI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERIC IGA; AUTOIMMUNE-DISEASE; ENDOTHELIAL-CELLS; MESANGIAL CELLS; SERUM IGA; B-CELLS; T-CELLS; CLEARANCE; INCREASE; MICE;
Keywords:
hematopoietic stem cells; glomerulonephritis; immunoglobulin A; transplantion immunology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Imasawa, T Jikei Univ, Sch Med, Dept Microbiol, Minato Ku, 3-25-8 Nishi Shinbashi, Tokyo 1058461, Japan Jikei Univ 3-25-8 Nishi Shinbashi Tokyo Japan 1058461 1, Japan
Citazione:
T. Imasawa et al., "Bone marrow transplantation attenuates murine IgA nephropathy: Role of a stem cell disorder", KIDNEY INT, 56(5), 1999, pp. 1809-1817

Abstract

Background. The pathogenesis of IgA nephropathy is still obscure. The aim of this study was to investigate whether the fundamental pathogenesis of IgA nephropathy lies in bone marrow stem cells (BMCs). Methods. We used donors of two different strains for bone marrow transplantation (BMT) into mice with a high content of serum IgA (ddY strain, HIGA mice), a murine model of IgA nephropathy. One group (B6-->HIGA, N = 5) received BMCs of C57BL/6j (B6) mice, and the other (HIGA-->HIGA, N = 8) were reconstituted with BMCs of HIGA mice. Results. Twenty-six weeks after BMT, in B6-->HIGA mice, mesangial depositsof IgA and C3 were statistically milder than those in HIGA-->HIGA mice. Light microscopic observations disclosed that glomerular sclerosis and mesangial matrix expansion in B6-->HIGA mice were decreased compared with those in HIGA-->HIGA mice. These B6-->HIGA mice also excreted less urinary albuminthan HIGA-->HIGA mice. Furthermore, serum levels of IgA in B6-->HIGA mice were markedly lower than those in HIGA-->HIGA mice. Size analysis of serum IgA revealed that macromolecular IgA were notably lower in B6-->HIGA mice than in HIGA-->HIGA mice. Conclusions. Our results suggest that qualitative and quantitative changesof serum IgA are determined at the level of stem cells, and that BMT from normal donors can attenuate glomerular lesions in HIGA mice. This approach may offer a new avenue to study the pathogenesis of IgA nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:00:07