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Titolo:
Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents
Autore:
Nobile, M; Begni, B; Giorda, R; Frigerio, A; Marino, C; Molteni, M; Ferrarese, C; Battaglia, M;
Indirizzi:
Ist Sci Eugenio Medea, Child Psychiat Unit, I-23842 Bosisio Parini, LC, Italy Ist Sci Eugenio Medea Bosisio Parini LC Italy I-23842 o Parini, LC, Italy Univ Milan, Dept Neurol, Monza, Italy Univ Milan Monza ItalyUniv Milan, Dept Neurol, Monza, Italy Ist Sci San Raffaele, Dept Neuropsychiat Sci, Milan, Italy Ist Sci San Raffaele Milan Italy , Dept Neuropsychiat Sci, Milan, Italy Univ Vita Salute San Raffaele, Dept Psychol, Dev Psychopathol Unit, Milan,Italy Univ Vita Salute San Raffaele Milan Italy sychopathol Unit, Milan,Italy
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
fascicolo: 11, volume: 38, anno: 1999,
pagine: 1396 - 1402
SICI:
0890-8567(199911)38:11<1396:EOSTPG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; OBSESSIVE-COMPULSIVE DISORDER; IMIPRAMINE BINDING; SEASONAL-VARIATION; H-3-IMIPRAMINE BINDING; BLOOD-PLATELETS; GENE; POLYMORPHISM; ILLNESS; ANXIETY;
Keywords:
serotonin transporter promoter; genetic variants; platelet serotonin uptake; major depression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Nobile, M Ist Sci Eugenio Medea, Child Psychiat Unit, Via Don Luigi Monza 20, I-23842 Bosisio Parini, LC, Italy Ist Sci Eugenio Medea Via Don Luigi Monza 20 Bosisio Parini LC Italy I-23842
Citazione:
M. Nobile et al., "Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents", J AM A CHIL, 38(11), 1999, pp. 1396-1402

Abstract

Objective: To investigate possible associations between serotonin transporter (5-HTT) promoter genotypic variants (I/I, I/s, and s/s) and differential regulation of platelet 5-HTT functionality parameters in a group of drug-naive depressed children and adolescents and healthy controls. Method: Children and adolescents with major depression (n = 18) defined by DSM-III-R criteria and normal controls (n = 21) were assessed both for platelet serotonin functionality and for genotypic variants on 5-HTT promoter region. Four parameters were considered: (1) serotonin uptake rate (V-max); (2) serotonin dissociation constant (K-m): (3) paroxetine binding and density of site (B-max); and (4) paroxetine dissociation constant (Kd) Results: Depressed children had lower V-max and K-m. Control subjects with I/I genotype had significantly higher V-max than control subjects with I/s and s/s genotype. Control subjects with I/I genotype also had significantly higher V-max than their depressed homologs. In contrast, V-max was not significantly different between depressed and nondepressed subjects who carried the other 2 genotypes. The 5-HTT promoter genotype, diagnoses, or their interaction had no effect on the other serotonin parameters. Conclusions: While showing a significant decrease of V-max and K-m in a group of drug-naive depressed children and adolescents, these data suggest that I/I genotype has a substantial effect on the decrease of V-max during a depressive episode.

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Documento generato il 21/01/20 alle ore 07:20:44