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Titolo:
Reactions of alpha-amino acid-N-carboxyanhydrides (NCAs) with organometallic palladium(0) and platinum(0) compounds: structure of a metallated NCA product and its role in polypeptide synthesis
Autore:
Goodwin, AA; Bu, XH; Deming, TJ;
Indirizzi:
Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA Univ CalifSanta Barbara Santa Barbara CA USA 93106 Barbara, CA 93106 USA Univ Calif Santa Barbara, Dept Chem, Santa Barbara, CA 93106 USA Univ Calif Santa Barbara Santa Barbara CA USA 93106 Barbara, CA 93106 USA Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA Univ Calif Santa Barbara Santa Barbara CA USA 93106 Barbara, CA 93106 USA
Titolo Testata:
JOURNAL OF ORGANOMETALLIC CHEMISTRY
fascicolo: 1, volume: 589, anno: 1999,
pagine: 111 - 114
SICI:
0022-328X(19991030)589:1<111:ROAA(W>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Keywords:
polypeptide; platinum; amino acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Deming, TJ Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara Santa Barbara CA USA 93106 93106 USA
Citazione:
A.A. Goodwin et al., "Reactions of alpha-amino acid-N-carboxyanhydrides (NCAs) with organometallic palladium(0) and platinum(0) compounds: structure of a metallated NCA product and its role in polypeptide synthesis", J ORGMET CH, 589(1), 1999, pp. 111-114

Abstract

Pt(COD)(2) and two equivalents of PEt3 were reacted with L-tert-leucine N-carboxyanhydride to yield the N-H oxidative addition product, H(PEt2)(2)PtNC(C(CH3)(3))HC(O)OC(O) (1). The structure and identity of 1 were determinedby X-ray crystallography. Pt(COD)(2) and two equivalents of PEt3 were alsoreacted with N-alpha-carbobenzyloxy-L-phenylalanine NCA to yield the O-C-5oxidative addition product, (PEt3)(2)PtC(O)C(CH2C6H5)HN(C(O)OBn)C(O)O (2). When 1 was reacted with excess gamma-benzyl-L-glutamate-N-carboxyanhydride(Glu NCA) in THF at room temperature, poly(gamma-benzyl-L-glutamate) was formed in good yield, but with no control over polymer molecular weight. NMRstudies showed that the N-carboxyanhydride ligand of 1 was responsible forpolymerization initiation, which confirmed that metallated N-carboxyanhydrides, or :activated monomers' are active, albeit inefficient, initiating species in NCA polymerizations. (C) 1999 Elsevier Science S.A. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:30:53