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Titolo:
Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex
Autore:
Rogers, RD; Owen, AM; Middleton, HC; Williams, EJ; Pickard, JD; Sahakian, BJ; Robbins, TW;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England MRC, Cognit & Brain Sci Unit, Cambridge CB2 2EF, England MRC Cambridge England CB2 2EF Brain Sci Unit, Cambridge CB2 2EF, England Univ Nottingham, Div Psychiat, Nottingham NG3 6AA, England Univ Nottingham Nottingham England NG3 6AA , Nottingham NG3 6AA, England Addenbrookes Hosp, Wolfson Brain Imaging Ctr, Cambridge CB2 2QQ, England Addenbrookes Hosp Cambridge England CB2 2QQ , Cambridge CB2 2QQ, England Addenbrookes Hosp, Dept Neurosurg, Cambridge CB2 2QQ, England AddenbrookesHosp Cambridge England CB2 2QQ , Cambridge CB2 2QQ, England Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, England Addenbrookes Hosp Cambridge England CB2 2QQ , Cambridge CB2 2QQ, England
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 20, volume: 19, anno: 1999,
pagine: 9029 - 9038
SICI:
0270-6474(19991015)19:20<9029:CBSLRA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; WORKING-MEMORY; ORBITOFRONTAL CORTEX; MACAQUE MONKEYS; FRONTAL-CORTEX; RHESUS-MONKEY; DAMAGE; BRAIN; CONNECTIONS; ARCHITECTURE;
Keywords:
(H2OPET)-O-15; decision making; orbitolateral PFC; orbitomedial PFC; frontal lobes; executive function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Rogers, RD Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England Univ Oxford Oxford England OX3 7JX t, Oxford OX3 7JX, England
Citazione:
R.D. Rogers et al., "Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex", J NEUROSC, 19(20), 1999, pp. 9029-9038

Abstract

Patients sustaining lesions of the orbital prefrontal cortex (PFC) exhibitmarked impairments in the performance of laboratory-based gambling, or risk-taking, tasks, suggesting that this part of the human PFC contributes to decision-making cognition. However, to date, little is known about the particular regions of the orbital cortex that participate in this function. In the present study, eight healthy volunteers were scanned, using H-2 O-15 PET technology, while performing a novel computerized risk-taking task. The task involved predicting which of two mutually exclusive outcomes would occur, but critically, the larger reward (and penalty) was associated with choice of the least likely outcome, whereas the smallest reward (and penalty) was associated with choice of the most likely outcome. Resolving these "conflicting" decisions was associated with three distinct foci of regional cerebral blood flow increase within the right inferior and orbital PFC: laterally, in the anterior part of the middle frontal gyrus [Brodmann area 10 (BA 10)], medially, in the orbital gyrus (BA 11), and posteriorly, in the anterior portion of the inferior frontal gyrus (BA 47). By contrast, increases in the degree of conflict inherent in these decisions was associated with only limited changes in activity within orbital PFC and the anterior cingulate cortex. These results suggest that decision making recruits neural activity from multiple regions of the inferior PFC that receive information from a diverse set of cortical and limbic inputs, and that the contribution of the orbitofrontal regions may involve processing changes in reward-related information.

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Documento generato il 10/04/20 alle ore 01:54:54