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Titolo:
Time course and permeation of synaptic AMPA receptors in cochlear nuclear neurons correlate with input
Autore:
Gardner, SM; Trussell, LO; Oertel, D;
Indirizzi:
Univ Wisconsin, Sch Med, Dept Physiol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Physiol, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 20, volume: 19, anno: 1999,
pagine: 8721 - 8729
SICI:
0270-6474(19991015)19:20<8721:TCAPOS>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPLEX-SPIKING NEURONS; CA2+ PERMEABILITY; STELLATE CELLS; INTRACELLULAR-RECORDINGS; HORSERADISH-PEROXIDASE; MICROSCOPIC FEATURES; GLUTAMATE RECEPTORS; RESPONSE PROPERTIES; SLICE PREPARATIONS; FUSIFORM CELLS;
Keywords:
mEPSCs; cochlear nuclei; AMPA receptors; auditory nerve; parallel fibers; time course; auditory pathways; philanthotoxin; calcium permeability; GluR2 subunit; polyamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Oertel, D Univ Wisconsin, Sch Med, Dept Physiol, 1300 Univ Ave, Madison, WI 53706 USA Univ Wisconsin 1300 Univ Ave Madison WI USA 53706 , WI 53706 USA
Citazione:
S.M. Gardner et al., "Time course and permeation of synaptic AMPA receptors in cochlear nuclear neurons correlate with input", J NEUROSC, 19(20), 1999, pp. 8721-8729

Abstract

AMPA receptors mediate rapid glutamatergic synaptic transmission. In the mammalian cochlear nuclei, neurons receive excitatory input from either auditory nerve fibers, parallel fibers, or both fiber systems. The functional correlates of differences in the source of input were examined by recording AMPA receptor-mediated, miniature EPSCs (mEPSCs) in whole-cell voltage-clamp mode from identified neurons. Bushy, octopus, and T-stellate cells of theventral cochlear nucleus (VCN) and tuberculoventral cells of the dorsal cochlear nucleus (DCN) receive most of their excitatory input from the auditory nerve; fusiform cells receive excitatory inputs from both the auditory nerve and parallel fibers; cartwheel cells receive excitatory input from parallel fibers alone. mEPSCs from bushy, octopus, T-stellate, and tuberculoventral cells had significantly faster decay time constants (0.35-0.40 msec) than did those from fusiform and cartwheel cells (1.32-1.79 msec). Some fusiform cells had two populations of mEPSCs with distinct time courses. mEPSCs in cells with auditory nerve input alone were inhibited by philanthotoxin, a blocker of calcium-permeable AMPA receptors, whereas mEPSCs in cells with parallel fiber input were not. Thus AMPA receptors postsynaptic to the auditory nerve differ from those postsynaptic to parallel fibers both in channel-gating kinetics and in their permeability to calcium. These results confirm the conclusion that synaptic AMPA receptors are specialized accordingto the source of input (Hunter et al., 1993; Rubio and Wenthold, 1997; Wang et al., 1998).

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Documento generato il 02/04/20 alle ore 17:36:44