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Titolo:
Amygdala neurons mediate acquisition but not maintenance of instrumental avoidance behavior in rabbits
Autore:
Poremba, A; Gabriel, M;
Indirizzi:
Univ Illinois, Beckman Inst, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Beckman Inst, Urbana, IL 61801 USA NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892NIMH, Neuropsychol Lab, Bethesda, MD 20892 USA Univ Illinois, Dept Psychol, Urbana, IL 61801 USA Univ Illinois Urbana ILUSA 61801 ois, Dept Psychol, Urbana, IL 61801 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 19, anno: 1999,
pagine: 9635 - 9641
SICI:
0270-6474(19991101)19:21<9635:ANMABN>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEAR-POTENTIATED STARTLE; BASOLATERAL AMYGDALA; HIPPOCAMPAL-FORMATION; SYNAPTIC PLASTICITY; TEMPORAL GRADIENT; EMOTIONAL MEMORY; BRAIN SYSTEMS; LESIONS; STIMULATION; EXPRESSION;
Keywords:
muscimol; GABA(A) agonist; temporary lesion; fiber-sparing lesion; rabbits; instrumental learning; avoidance learning; discriminative conditioning; retention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Gabriel, M Univ Illinois, Beckman Inst, 405 N Mathews, Urbana, IL 61801 USA Univ Illinois 405 N Mathews Urbana IL USA 61801 a, IL 61801 USA
Citazione:
A. Poremba e M. Gabriel, "Amygdala neurons mediate acquisition but not maintenance of instrumental avoidance behavior in rabbits", J NEUROSC, 19(21), 1999, pp. 9635-9641

Abstract

Whereas the amygdala is generally understood to be involved in aversively motivated learning, the specific associative function of the amygdala remains controversial. This study addressed the amygdalar role in mediation of discriminative instrumental avoidance learning of rabbits. Bilateral microinjection of the GABA receptor agonist muscimol centered in the basolateral nucleus of the amygdala was given to inactivate amygdalar neurons at each ofthree stages of acquisition. The absence of behavioral learning in rabbitstrained immediately after amygdalar inactivation confirmed previous results with electrolytic lesions. The absence of savings during training after muscimol had become ineffective indicated an amygdalar role in the establishment of acquisition-relevant neural plasticity, not simply in the expression of the learned response. A time-limited role of the amygdala in instrumental avoidance learning was indicated by the finding that intra-amygdalar muscimol failed to disrupt performance of the well-established avoidance response. The passage of time alone (with no training trials) was sufficient toreduce amygdalar involvement in response performance. These results and demonstrations that other limbic system areas make time-limited contributionsto learning indicate that the amygdala is part of a larger intermediate memory system that supports learning and performance before habit consolidation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:14:49