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Titolo:
Anterograde and retrograde amnesia after lesions to frontal cortex in rats
Autore:
Winocur, G; Moscovitch, M;
Indirizzi:
Baycrest Ctr Geriatr Care, Rotman Res Inst, Toronto, ON M6A 2E1, Canada Baycrest Ctr Geriatr Care Toronto ON Canada M6A 2E1 o, ON M6A 2E1, Canada Trent Univ, Dept Psychol, Peterborough, ON K9J 7B8, Canada Trent Univ Peterborough ON Canada K9J 7B8 eterborough, ON K9J 7B8, Canada Univ Toronto, Dept Psychol, Toronto, ON M5S 3G3, Canada Univ Toronto Toronto ON Canada M5S 3G3 ychol, Toronto, ON M5S 3G3, Canada Univ Toronto, Dept Psychiat, Toronto, ON M5S 3G3, Canada Univ Toronto Toronto ON Canada M5S 3G3 chiat, Toronto, ON M5S 3G3, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 19, anno: 1999,
pagine: 9611 - 9617
SICI:
0270-6474(19991101)19:21<9611:AARAAL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMORY IMPAIRMENT; PREFRONTAL CORTEX; HIPPOCAMPAL-FORMATION; EPISODIC MEMORY; REMOTE MEMORY; DAMAGE; RETRIEVAL; DEFICITS;
Keywords:
anterograde amnesia; retrograde amnesia; food-preference test; lesions; frontal cortex; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Winocur, G Baycrest Ctr Geriatr Care, Rotman Res Inst, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada Baycrest Ctr Geriatr Care 3560 Bathurst St Toronto ON Canada M6A 2E1
Citazione:
G. Winocur e M. Moscovitch, "Anterograde and retrograde amnesia after lesions to frontal cortex in rats", J NEUROSC, 19(21), 1999, pp. 9611-9617

Abstract

A socially acquired food-preference test was used to assess effects of lesions to the frontal cortex on anterograde and retrograde memory in rats. InExperiment 1, there was no effect of lesion when rats were administered a two-choice test in which the target food was to be selected in the presenceof a single distractor. In Experiment 2, a three-choice memory test was administered in which the target food was presented along with two equally palatable alternatives. In the latter test, lesioned groups displayed anterograde amnesia that increased with the length of the interval between postoperative acquisition and test, and a severe retrograde amnesia that extended equally over the entire range of intervals between preoperative acquisitionand test. This outcome, which contrasted with the pattern of memory loss previously observed in rats with hippocampal lesions on this test, was interpreted as evidence for the strategic role of the frontal lobes in directingresponse selection and retrieval processes in memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:10:05