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Titolo:
Learning induces a CDC2-related protein kinase, KKIAMRE
Autore:
Gomi, H; Sun, W; Finch, CE; Itohara, S; Yoshimi, K; Thompson, RF;
Indirizzi:
Univ So Calif, Program Neurosci, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 eurosci, Los Angeles, CA 90089 USA RIKEN Brain Sci Inst, Lab Behav Genet, Wako, Saitama, Japan RIKEN Brain Sci Inst Wako Saitama Japan ehav Genet, Wako, Saitama, Japan Metab Therapeut Inc, San Diego, CA 92121 USA Metab Therapeut Inc San Diego CA USA 92121 t Inc, San Diego, CA 92121 USA Sankyo Co Ltd, Neurosci Res Labs, Tokyo 140, Japan Sankyo Co Ltd Tokyo Japan 140 o Ltd, Neurosci Res Labs, Tokyo 140, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 21, volume: 19, anno: 1999,
pagine: 9530 - 9537
SICI:
0270-6474(19991101)19:21<9530:LIACPK>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CLASSICALLY-CONDITIONED BEHAVIOR; CEREBELLAR INTERPOSITUS NUCLEUS; NICTITATING-MEMBRANE RESPONSE; NEURONAL CDC2-LIKE KINASE; APLYSIA SENSORY NEURONS; EYE-BLINK RESPONSE; MUTANT MICE; MEMORY TRACE; REVERSIBLE LESIONS;
Keywords:
cerebellum; eyeblink conditioning; interpositus nucleus; RNA synthesis inhibition; learning-induced protein synthesis; KKIAMRE motif;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Thompson, RF Univ So Calif, Program Neurosci, Univ Pk, Los Angeles, CA 90089 USA Univ So Calif Univ Pk Los Angeles CA USA 90089 , CA 90089 USA
Citazione:
H. Gomi et al., "Learning induces a CDC2-related protein kinase, KKIAMRE", J NEUROSC, 19(21), 1999, pp. 9530-9537

Abstract

To elucidate molecular mechanisms in learning and memory, we analyzed expression of mRNAs in brains of rabbits undergoing eyeblink conditioning. Infusion of the transcription inhibitor actinomycin D into the cerebellar interpositus nucleus reversibly blocked learning but not performance of the conditioned response. Differential display PCR analysis of cerebellar interpositus RNAs from trained and pseudotrained rabbits identified a 207 bp band that was induced with learning. The fragment was used to isolate a cDNA from a lambda gt11 rabbit brain library containing a 1698 bp open reading frame. The deduced amino acid sequence contains the KKIAMRE motif, which is conserved among cell division cycle 2 (cdc2)-related kinases. These results suggest that there is a new category of cdc2-related kinases in the brain whosefunction may be important in learning and memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:42:49