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Titolo:
The nuclear/mitotic apparatus protein NuMA is a component of the somatodendritic microtubule arrays of the neuron
Autore:
Ferhat, L; Cook, C; Kuriyama, R; Baas, PW;
Indirizzi:
Univ Wisconsin, Sch Med, Dept Anat, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Med, Dept Anat, Madison, WI 53706 USA Univ Minnesota, Sch Med, Dept Cell Biol & Neuroanat, Minneapolis, MN 55455USA Univ Minnesota Minneapolis MN USA 55455 uroanat, Minneapolis, MN 55455USA
Titolo Testata:
JOURNAL OF NEUROCYTOLOGY
fascicolo: 12, volume: 27, anno: 1998,
pagine: 887 - 899
SICI:
0300-4864(199812)27:12<887:TNAPNI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLARITY ORIENTATION; MITOTIC SPINDLE; AXONAL MICROTUBULES; POSTMITOTIC NEURONS; CYTOPLASMIC DYNEIN; MITOSIS; PHOSPHORYLATION; ORGANIZATION; EXPRESSION; POLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Baas, PW Univ Wisconsin, Sch Med, Dept Anat, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 Anat, Madison, WI 53706 USA
Citazione:
L. Ferhat et al., "The nuclear/mitotic apparatus protein NuMA is a component of the somatodendritic microtubule arrays of the neuron", J NEUROCYT, 27(12), 1998, pp. 887-899

Abstract

Neurons are terminally post-mitotic cells that utilize their microrubule arrays for the growth and maintenance of axons and dendrites rather than forthe formation of mitotic spindles. Recent studies from our laboratory suggest that the mechanisms that organize the axonal and dendritic microtubule arrays may be variations on the same mechanisms that organize the mitotic spindle in dividing cells. In particular, we have identified molecular motorproteins that serve analogous functions in the establishment of these seemingly very different microtubule arrays. In the present study, we have sought to determine whether a non-motor protein termed NuMA is also a componentof both systems. NuMA is a similar to 230 kDa structural protein that is present exclusively in the nucleus during interphase. During mitosis, NuMA forms aggregates that interact with microtubules and certain motor proteins. As a result of these interactions, NuMA is thought to draw together the minus-ends of microtubules, thereby helping to organize them into a bipolar spindle. In contrast to mitotic cells, post-mitotic neurons display NuMA both in the nucleus and in the cytoplasm. NuMA appears as multiple small particles within the somatodendritic compartment of the neuron, where its levelsincrease during early dendritic differentation. A partial but not completecolocalization with minus-ends of microtubules is suggested by the distribution of the particles during development and during drug treatments that alter the microtubule array. These observations provide an initial set of clues regarding a potentially important function of NuMA in the organization of microtubules within the somatodendritic compartment of the neuron.

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Documento generato il 04/12/20 alle ore 19:19:37