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Titolo:
Antipsychotic-like effect of the AMPA receptor antagonist LY326325 as indicated by suppression of conditioned avoidance response in the rat
Autore:
Mathe, JM; Fagerquist, MV; Svensson, TH;
Indirizzi:
Karolinska Inst, Dept Physiol & Pharmacol, Sect Neuropsychopharmacol, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 ol, SE-17177 Stockholm, Sweden
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 9-10, volume: 106, anno: 1999,
pagine: 1003 - 1009
SICI:
0300-9564(1999)106:9-10<1003:AEOTAR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIZOCILPINE MK-801; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; BLOCKADE; HYPERLOCOMOTION; NEUROLEPTICS; STEREOTYPY; ACTIVATION; ACID;
Keywords:
conditioned avoidance response; AMPA; kainate; behavior; antipsychotic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Svensson, TH Karolinska Inst, Dept Physiol & Pharmacol, Sect Neuropsychopharmacol, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 Stockholm, Sweden
Citazione:
J.M. Mathe et al., "Antipsychotic-like effect of the AMPA receptor antagonist LY326325 as indicated by suppression of conditioned avoidance response in the rat", J NEURAL TR, 106(9-10), 1999, pp. 1003-1009

Abstract

The effect of LY326325, a novel AMPA receptor antagonist, on the conditioned avoidance response and catalepsy was investigated in the rat. The conditioned avoidance response is a behavioral methodology which is regarded to predict potential antipsychotic efficacy of experimental drugs. Catalepsy ratings were utilized to assess the putative propensity of LY325326 to induceextrapyramidal side effects. Systemic administration of LY326325, 18 mg/kgsubcutaneously, caused a selective suppression of conditioned avoidance response, without effect on escape behavior or intertrial crosses. In addition, no catalepsy was observed. Our present and previous results support an antipsychotic effect of AMPA receptor antagonists with a low liability for extrapyramidal side effects, i.e. pharmacological effects consonant with an atypical antipsychotic profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:33:26