Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Metallothionein: Localization in human transplant endomyocardium, relationto cytokines and allograft function
Autore:
Baba, HA; Schmid, KW; Takeda, A; Wichter, T; Gradaus, R; Erren, M; Plenz, G; Grabellus, F; Tjan, TDT; Deng, MC;
Indirizzi:
Univ Munster, Gerhard Domagk Inst Pathol, Dept Pathol, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 pt Pathol, D-48149 Munster, Germany
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 10, volume: 18, anno: 1999,
pagine: 963 - 971
SICI:
1053-2498(199910)18:10<963:MLIHTE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; HEART-TRANSPLANTATION; CARDIAC TRANSPLANTATION; INTERLEUKIN-2 RECEPTOR; ZINC CLUSTERS; INDUCTION; REJECTION; STRESS; SERUM; HEMODYNAMICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Baba, HA Univ Munster, Gerhard Domagk Inst Pathol, Dept Pathol, Domagkstr 17, D-48149 Munster, Germany Univ Munster Domagkstr 17 Munster Germany D-48149 nster, Germany
Citazione:
H.A. Baba et al., "Metallothionein: Localization in human transplant endomyocardium, relationto cytokines and allograft function", J HEART LUN, 18(10), 1999, pp. 963-971

Abstract

Background: The aim of this study was to investigate the role of metallothionein in cardiac transplants in relation to cytokines and allograft function. Recent studies have revealed an association of allograft dysfunction with elevated proinflammatory cytokines independent of cellular rejection. Inanimal experiments, cytokines induced overexpression of metallothionein, alow-molecular-weight protein implicated in cellular stress response. Methods: In 105 consecutive biopsies from 15 patients during the first 3 months after heart transplantation, metallothionein expression was investigated immunohistochemically. Its relation to serum interleukin-6, tumor necrosis factor-alpha, interleukin-2 (IL-2), soluble interleukin-2 receptor rejection, and echocardiographic parameters was determined. Forty-three biopsies of 12 patients with idiopathic ventricular tachycardia served as controls. Results: Metallothionein expression was demonstrated in small vessels, cardiomyocytes, fibrocytes, and interstitial round cells. A positive relation between interleukin-6 levels and the number of metallothionein-positive small vessels (p < 0.028) was observed. Patients with lower serum IL-2 levels showed significantly higher numbers of metallothionein-positive small vessels (p < 0.043). Grafts with prolonged ischemic time (>150 minutes) showed asignificantly higher myocardial metallothionein score (p < 0.021). Metallothionein expression was associated with lower fractional shortening, largerleft ventricular end-systolic diameter, and lower mean arterial pressure but not with acute cellular rejection. Conclusions: Metallothionein expression is associated with elevated interleukin-6 and decreased interleukin-2 serum levels and left ventricular allograft dysfunction in the absence of rejection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:18:34