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Titolo:
Myocardial kinetics of (99m)technetium-Q agents - Studies in isolated cardiac myocyte, isolated perfused rat heart, and canine regional myocardial ischemia models
Autore:
McGoron, AJ; Biniakiewicz, D; Millard, RW; Kumar, A; Kennedy, SC; Roszell, NJ; Gabel, M; Huth, C; Walsh, RA; Gerson, MC;
Indirizzi:
Univ Cincinnati, Coll Med, Dept Radiol, Div Nucl Res,EL Saenger Radioisotope Lab, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 ope Lab, Cincinnati, OH 45267 USA Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Biophys, Cincinnati, OH 45267 USA Univ Cincinnati, Coll Med, Dept Internal Med, Div Cardiol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Cardiol, Cincinnati, OH 45267 USA
Titolo Testata:
INVESTIGATIVE RADIOLOGY
fascicolo: 11, volume: 34, anno: 1999,
pagine: 704 - 717
SICI:
0020-9996(199911)34:11<704:MKO(A->2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; CORONARY-ARTERY DISEASE; BLOOD-FLOW; TC-99M SESTAMIBI; METHOXYISOBUTYL ISONITRILE; DEFECT SIZE; TL-201; REDISTRIBUTION; TETROFOSMIN; RETENTION;
Keywords:
transport kinetics; perfusion imaging; ischemia; radioisotope dilution technique;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: McGoron, AJ Univ Cincinnati, Coll Med, Dept Radiol, Div Nucl Res,EL Saenger Radioisotope Lab, POB 670577, Cincinnati, OH 45267 USA Univ Cincinnati POB 670577 Cincinnati OH USA 45267 H 45267 USA
Citazione:
A.J. McGoron et al., "Myocardial kinetics of (99m)technetium-Q agents - Studies in isolated cardiac myocyte, isolated perfused rat heart, and canine regional myocardial ischemia models", INV RADIOL, 34(11), 1999, pp. 704-717

Abstract

OBJECTIVE. Based on reports of high cellular uptake and low plasma bindingof nonreducible mixed ligand Tc(III) cations (Q complexes) and high linearuptake versus blood how of Tc-99m-Q3 in canine hearts, the authors hypothesized that the two Q complexes, Tc-99m-Q63 and Tc-99m-Q64, would have high cell uptake and better differentiation between ischemic and nonischemic myocardium compared with other Tc-99m-based compounds,METHODS. Uptake and retention kinetics of Tc-99m-Q63 and Tc-99m-Q64 were measured in isolated rat cardiac myocytes, isolated perfused rat hearts, andintact canines and compared with previously reported Q-based compounds, a clinically available Tc-99m perfusion agent (sestamibi), and Tl-201. RESULTS. Uptake of Q63, Q64, and sestamibi by isolated cardiac myocytes was similar, Maximum extraction (E-max) of Q64 by isolated perfused rat hearts was greatest among the Tc-99m agents (P < 0.02), but net extraction (E-net) of Q64 was not different from Q63 or sestamibi 3 minutes after tracer injection, By 15 minutes, Tl-201 E-net was lower than Q63, Q64, and sestamibi(P < 0.05). Among Tc-99m agents, the uptake versus flow of Q3, Q63, and Q64 by canine heart was superior to Q12 and sestamibi (P < 0.05). CONCLUSIONS. The activity of Q63 and Q64 in the myocardium is related to actual myocardial blood dow over a broad, clinically relevant range of flows. The ischemic-to-normal zone activity distributions of Q63 and Q64 approximate actual flow in a manner more like that of Tl-201 than sestamibi or Q12, These results provide a rational foundation in support of further evaluation of Q63 and Q64 in humans.

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Documento generato il 17/01/21 alle ore 18:30:44