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Titolo:
Repeated inhalation of low doses of cat allergen that do not induce clinical symptoms increases bronchial hyperresponsiveness and eosinophil cationicprotein levels
Autore:
de Blay, F; Krieger, P; Spirlet, F; Moreau, L; Duvernelle, C; Kassel, O; Kopferschmitt, MC; Gasser, B; Demangeat, C; Pauli, G; Frossard, N;
Indirizzi:
Hop Univ, Hop Lyautey, Serv Pneumol 1, INSERM,U425, F-67091 Strasbourg, France Hop Univ Strasbourg France F-67091 SERM,U425, F-67091 Strasbourg, France Hop Univ, Inst Anatomopathol, F-67091 Strasbourg, France Hop Univ Strasbourg France F-67091 omopathol, F-67091 Strasbourg, France Hop Univ, Nucl Med Lab, F-67091 Strasbourg, France Hop Univ Strasbourg France F-67091 l Med Lab, F-67091 Strasbourg, France Fac Pharm, Illkirch, France Fac Pharm Illkirch FranceFac Pharm, Illkirch, France
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 2, volume: 120, anno: 1999,
pagine: 158 - 165
SICI:
1018-2438(199910)120:2<158:RIOLDO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOALVEOLAR LAVAGE; BLOOD EOSINOPHILS; ASTHMATIC AIRWAYS; SERUM; INFLAMMATION; CHALLENGE; FLUID; EXPOSURE; CELLS; RADIOIMMUNOASSAY;
Keywords:
eosinophil; cat allergen; inflammation; bronchial hyperresponsiveness; eosinophil cationic protein; bronchial asthma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: de Blay, F Hop Univ, Hop Lyautey, Serv Pneumol 1, INSERM,U425, BP 426, F-67091 Strasbourg, France Hop Univ BP 426 Strasbourg France F-67091 1 Strasbourg, France
Citazione:
F. de Blay et al., "Repeated inhalation of low doses of cat allergen that do not induce clinical symptoms increases bronchial hyperresponsiveness and eosinophil cationicprotein levels", INT A AL IM, 120(2), 1999, pp. 158-165

Abstract

The aim of this study was to investigate whether repeated exposure to subclinical doses of cat allergens, not inducing asthma symptoms, could affect eosinophil cationic protein (ECP) levels in bronchoalveolar lavage (BAL) orin peripheral blood, without the appearance of clinical symptoms. Twelve patients with mild asthma, all sensitized to cats and not exposed to cat allergen at home, underwent a series of inhalations of cat allergen or placebofor 8 days over 2 weeks. A methacholine challenge was performed before andafter the allergen and saline exposures, and BAL and blood were sampled for ECP measurements and eosinophil counts. No patients experienced asthma symptoms. However, PD20 methacholine (geometric mean) decreased significantlyfrom 263 mu g before to 126 mu g after inhalation of allergen. Inhalation of saline did not induce any significant change in PD20. The change in log PD20 before and after cat allergen exposure was statistically different from the change in log PD20 before and after saline. Median ECP levels in BAL and serum increased significantly after allergen exposure, from 0.8 to 3.1 mu g/l (p<0.02) and from 15.9 to 31.4 mu g/l (p<0.05), respectively. No change was observed after saline inhalations. The change in BAL and serum ECP levels was statistically significant compared to that in the control group. The number of eosinophils did not change, however, nor did IL-5 and RANTESlevels in BAL and serum. In conclusion, our results show that (1) exposureof asthma patients to repeated low doses of allergen, which did not provoke any clinical symptoms, is capable of inducing a local eosinophil activation associated with an increase in nonspecific bronchial hyperresponsivenessand (2) the increase in serum ECP levels due to eosinophil activation precedes the occurrence of asthma symptoms and may thus be a marker of allergenexposure in allergic asthma.

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Documento generato il 23/01/21 alle ore 00:59:43